205448-65-3

Basic information

• Product Name: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
• Synonyms: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate;1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl ester;7-Methoxy-4-oxo-1,4-dihydro-quinoline-6-carboxylic acid methyl ester;Lenvatinib Intermediate3;FMX14227-A2;7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate;methyl 4-hydroxy-7-methoxyquinoline-6-carboxylate;4-dihydroquinoline-6-carboxylate
• CAS NO: 205448-65-3
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22004
• EINECS: -0
• Mol File: 205448-65-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 421.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.267±0.06 g/cm3(Predicted)
• PKA: -0.53±0.50(Predicted)
• CAS DataBase Reference: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate(205448-65-3)
• EPA Substance Registry System: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate(205448-65-3)

Safety Data

• Hazardous Substances Data: 205448-65-3(Hazardous Substances Data)

Usage

General Description

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate is a chemical compound with the molecular formula C13H11NO4. It is a derivative of quinoline, a heterocyclic organic compound. Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate has various potential applications in the field of organic synthesis and pharmaceuticals. Its unique structure and properties make it an interesting molecule for further research and development. It is important to handle this chemical with care and follow proper safety protocols when working with it in a laboratory setting.

Upstream product

• 65-49-6 4-Aminosalicylic acid 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 39106-79-1 methyl 2-methoxy-4-nitrobenzoate 
• 205448-64-2 methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-amino)-2-methoxybenzoate 

Downstream Products

• 417716-92-8 lenvatinib 
• 417724-81-3 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxamide 
• 205448-66-4 methyl 4-chloro-7-methoxyquinoline-6-carboxylate 

Relevant articles and documents

Method for synthesizing lenvatinib

The invention belongs to the field of chemical pharmacy, and specifically relates to a method for synthesizing lenvatinib. The method comprises the following steps: step 1, taking 4-aminosalicylic acid as a raw material, and preparing 4-chloro-7-methoxyquinoline-6-formamide through methylation, condensation with meldrum's acid, high-temperature cyclization, chlorination and ammoniation; step 2, taking 3-chloro-4-aminophenol as a raw material, and reacting with phenyl chloroformate and cyclopropylamine to obtain 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea; and step 3, enabling the 4-chloro-7-methoxyquinoline-6-formamide prepared in step 1 to react with the 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea prepared in step 2 under action of potassium tert-butoxide to obtain the lenvatinib. The invention provides a brand-new route for synthesising the lenvatinib. The used reagent is cheap and is easily available, is simple in operation, has a yield higher than that of other methods, and is easy for industrial production.

NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to novel polymorphs of 4-[3-chloro-4-(N'- cyclopropyl ureido) phenoxy]-7- methoxyquinoline- 6- carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the pres

4-oxo-7-methoxy-1,4-dihydroquinoline-6-methyl formate synthesis method

The invention relates to a 4-oxo-7-methoxy-1,4-dihydroquinoline-6-methyl formate synthesis method. The method includes that 4-nitro-methyl-2-methoxybenzoate which is taken as a starting material is subjected to friedel-crafts reaction, reduction and ammonolysis cyclization to obtain a target compound. By adoption of classic reaction, a step of decarboxylation in diphenyl ether at a high temperature of 180-220 DEG C in an existing universal method is avoided, problems in production are solved, safety and environment friendliness are achieved, and production enlargement is benefited. In addition, the synthesis method has advantages of high reaction efficiency, high yield, high purity, low cost and the like.