205449-09-8

Upstream product

• 186581-53-3 diazomethane 

Downstream Products

• 22976-90-5 Polyoxin L 
• 249765-15-9 methyl (2R)-2-[(tert-butoxycarbonyl)amino]-2-[(4S,5S)-5-([1-(tert-butyl)-1,1-diphenylsilyl]oxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanoate 
• 249765-14-8 Methyl 2-azido-5-O-tert-butyldiphenylsilyl-2-deoxy-3,4-O-isopropylidene-L-lyxonate 
• 205449-11-2 (S)-[(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-trifluoromethanesulfonyloxy-acetic acid methyl ester 
• 205449-18-9 (R)-Acetoxy-[(4R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-acetic acid methyl ester 
• 205449-07-6 Methyl 5-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-L-lyxonate 
• 205449-13-4 Methyl 5-O-tert-butyldiphenylsilyl-2-(tert-butoxycarbonyl)amino-2-deoxy-3,4-O-isopropylidene-L-xylonate 
• 205449-12-3 Methyl 2-azido-5-O-tert-butyldiphenylsilyl-2-deoxy-3,4-O-isopropylidene-L-xylonate 
• 205449-15-6 Benzyl 5-O-(aminocarbonyl)-2-(tert-butoxycarbonyl)amino-2-deoxy-3,4-O-isopropylidene-L-xylonate 
• 205449-10-1 Methyl 5-O-tert-butyldiphenylsilyl-3,4-O-isopropylidene-L-xylonate 

Relevant academic research and scientific papers

Total syntheses of (-)-polyoxin J and (-)-polyoxin L

A convenient synthesis of the N-protected L-carbamoylpolyoxamic acid derivative (7) from 4-O-tert-butyldiphcnylsilyl-2,3-isopropylidene-L-threose (8) using vinylmagnesium bromide and its application to the total syntheses of the peptidyl nucleoside antibiotics, polyoxins J (1) and L (2), are described.