205494-44-6Relevant academic research and scientific papers
Convenient green preparation of dipeptides using unprotected α-amino acids
Ezawa, Tetsuya,Jung, Seunghee,Kawashima, Yuya,Noguchi, Takuya,Imai, Nobuyuki
, p. 75 - 83 (2017)
Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine by an ecological and convenient method in which the protection of C-terminals is not needed.
Convenient peptide synthesis without protection of C-Terminals
Noguchi, Takuya,Tehara, Naoka,Uesugi, Yuki,Jung, Seunghee,Imai, Nobuyuki
, p. 42 - 43 (2012/03/11)
Condensation of carboxylic acids 1 and 5 with unprotected α-amino acids 2 via activation by ethyl chloroformate and triethylamine proceeded effectively to afford the corresponding amides in 5099% yields. Tripeptide 7c was obtained in 42% yield from the dipeptide 6c in a similar manner.
