151418-18-7

Basic information

• Product Name: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid
• Synonyms: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid
• CAS NO: 151418-18-7
• Molecular Weight: 222.241
• Mol File: 151418-18-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid(CAS DataBase Reference)
• NIST Chemistry Reference: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid(151418-18-7)
• EPA Substance Registry System: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid(151418-18-7)

Safety Data

• Hazardous Substances Data: 151418-18-7(Hazardous Substances Data)

Upstream product

• 56-86-0 L-glutamic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 73443-73-9 ethyl (4-mercaptophenyl)carbamate 
• 24722-24-5 N-(4-cyanophenyl)-3-phenylpropanamide 
• 316146-27-7 N-(4-bromophenyl)-3-phenylpropanamide 
• 1456813-79-8 N-(3,5-dinitrophenyl)-3-phenylpropanamide 
• 71231-25-9 N-(4-methylphenyl)-3-phenylpropanamide 
• 3271-81-6 hydrocinnamanilide 
• 119520-57-9 N-(4-nitrophenyl)-3-phenylpropionamide 
• 316146-16-4 N-(4-ethoxycarbonylphenyl)-3-phenylpropionamide 
• 425372-18-5 N-(2,3,4,5,6-pentafluorophenyl)-3-phenylpropanamide 
• 70414-24-3 ethyl pentafluorophenylcarbamate 
• 5298-86-2 N-(4-fluorophenyl)-3-phenylpropanamide 
• 152189-81-6 N-(4-chlorophenyl)-3-phenylpropanamide 
• 2621-80-9 ethyl p-chlorophenylcarbamate 
• 4270-31-9 N-(4-ethoxyphenyl)-3-phenylpropanamide 

Relevant articles and documents

Tributylphosphine-Catalyzed Acylations of Alcohols: Scope and Related Reactions

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Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity

Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.

Ecological base-conditioned preparation of dipeptides using unprotected α-amino acids containing hydrophilic side chains

The coupling reactions of 3-phenylpropanoic acid and Ncarboxybenzyl á-amino acids with unprotected á-amino acids containing hydrophilic side chains such as aliphatic alcohol, aromatic alcohol, thiol, carboxylic acid, and amide afforded the corresponding amides in 6696% yield without racemization via the corresponding mixed carbonic carboxylic anhydrides under basic conditions through an ecological green synthetic method.