205494-61-7

Upstream product

• 103-26-4 Methyl cinnamate 
• 618-36-0 rac-methylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 86980-83-8 (-)-(R)-phenylpropiolic acid 1-phenylethylamine 

Downstream Products

• 205494-63-9 N-(S)-α-methylbenzyl thiocinnamamide 

Relevant academic research and scientific papers

New Efficient Eco-Friendly Supported Catalysts for the Synthesis of Amides with Antioxidant and Anti-Inflammatory Properties

A new environmentally friendly approach for the synthesis of idrocilamide (1), a marketed myorelaxant and anti-inflammatory agent, is reported herein. The synthetic strategy involves a solvent-free aminolysis reaction catalyzed by zinc-containing species

Organocatalytic Trans Semireduction of Primary and Secondary Propiolamides: Substrate Scope and Mechanistic Studies

We report a chemoselective, phosphine-catalyzed semireduction of primary and secondary propiolamides. In the presence of stoichiometric pinacolborane and catalytic n-tributylphosphine, a variety of propiolamides were successfully converted to the corresponding acrylamides in excellent yield with (E)-stereoselectivity. The reaction condition is tolerant of various functional groups including alkene, alkyne, ketone, or ester. Deuterium labeling studies established that the hydride from activated pinacolborane is added to the α-carbon and the proton on the amide nitrogen is abstracted by the ?-carbon to furnish the (E)-acrylamides. DFT calculations revealed a clear energetic driving force for the (E)- over the (Z)-isomer. (Figure presented.).

Efficient synthesis of new N-benzyl- or N-(2-furylmethyl)cinnamamides promoted by the 'green' catalyst boric acid, and their spectral analysis

New N-benzyl- or N-(2-furylmethyl)cinnamamides were prepared in good to excellent yields by amidation reactions between cinnamic acid and benzylamines or (2-furylmethyl)amine in the presence of 5 mol% boric acid. All the cinnamamides were characterized by IR and 1H and 13C NMR spectroscopy. Georg Thieme Verlag Stuttgart.

A novel carbonylative decomplexation of alkyne-dicobalt hexacarbonyls: Hyrocarbamoylation of alkynes

A novel carbonylative decomplexation of alkyne-dicobalt hexacarbonyls, i.e. hydrocarbamoylation of alkynes, was carried out by reaction of the complexes with 10 equiv, of primary and secondary amines.

Generation and Cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III: Control of diastereoselectivity using homochiral auxiliaries

Activated 2-(N-acylamino)-1-thia-1,3-dienes undergo efficient diastereoselective Diels-Alder cycloadditions giving access to thiopyrans of high optical purity. By variation of the position and nature of the chiral auxiliaries we have been able to induce a

Synthesis of Optically Active Amides from β-Furyl and β-Phenyl Esters by way of Enzymatic Aminolysis

Candida antarctica lipase efficiently catalyses the aminolysis of non-activated esters with a β-furyl or β-phenyl group; use of racemic amines gives the corresponding optically active amides with high enantiomeric axcess.