205502-81-4

Upstream product

• 16814-26-9 bis(2-methylbenzyl) ether 
• 118-93-4 o-hydroxyacetophenone 
• 933-88-0 ortho-toluoyl chloride 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 58134-78-4 1-(2-hydroxyphenyl)-3-(o-tolyl)propane-1,3-dione 
• 116115-49-2 2-(2-methylphenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Novel Bifunctionalization of Activated Methylene: Base-Promoted Trifluoromethylthiolation of β-Diketones with Trifluoromethanesulfinyl Chloride

A novel bifunctionalization of activated methylene was achieved successfully through the base-promoted trifluoromethylthiolation of β-diketones or β-ketoesters with trifluoromethanesulfinyl chloride. A series of α-trifluoromethylthiolated α-chloro-β-diketones and α-chloro-β-ketoesters were obtained in moderate to good yields under mild conditions. When β-diketones containing a phenyl group with a hydroxyl or amino substituent at the ortho position were used as substrates, intramolecular trifluoromethylthiolation/cyclization reaction took place to give the corresponding cyclic products. Furthermore, the protocol could be extended to perfluoroalkylthiolation with the sodium perfluoroalkanesulfinate/POCl3 system. On the basis of experimental results, plausible mechanisms are proposed.

Nickel-catalyzed oxidative esterification of formamides with 1,3-dicarbonyl compounds under mild reaction conditions

Synthesis of enol carbamates was achieved via nickel-catalyzed oxidative coupling of formamides with 1,3-dicarbonyl compounds in the presence of tert-butyl hydroperoxide at 40?°C. Various derivatives of enol carbamates were synthesized by this method in good to excellent yields.

Copper-catalyzed oxidative C-O bond formation of 2-acyl phenols and 1,3-dicarbonyl compounds with ethers: Direct access to phenol esters and enol esters

A copper-catalyzed oxidative coupling of 2-carbonyl-substituted phenols and 1,3-dicarbonyl compounds with a wide range of dibenzyl or dialkyl ethers is described. This protocol provides an efficient preparation of phenol esters and enol esters in good yields with high chemoselectivity. This method represents an alternative protocol for classical esterification reactions.

CuO nanoparticles supported on α-Fe2O3-modified CNTs: A magnetically separable catalyst for oxidative C-O coupling of formamides with 1,3-dicarbonyl compounds This article is dedicated to memory of Rais Ali Delvari

Oxidative coupling of formamides with 1,3-dicarbonyl compounds to prepare enol carbamates was effected in the presence of CuO nanoparticles supported on α-Fe2O3-modified carbon nanotubes (CNTs at α-Fe2O3@CuO) as an environmentally friendly heterogeneous catalyst. The simple preparation, and the ability to be recycled and magnetically separated are salient features of this catalytic system.