205520-79-2

Basic information

• Product Name: (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester
• Synonyms: (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester
• CAS NO: 205520-79-2
• Molecular Weight: 285.386
• Mol File: 205520-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester(205520-79-2)
• EPA Substance Registry System: (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester(205520-79-2)

Safety Data

• Hazardous Substances Data: 205520-79-2(Hazardous Substances Data)

Upstream product

• 37662-05-8 ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester 
• 1165952-91-9 cyclohexa-1,3-diene 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant articles and documents

Enantio- and Diastereo-selective Synthesis of Pipecolic Acid Derivatives using the Aza-Diels-Alder Reaction of Imines with Dienes

Optically active pipecolic acid derivatives can be prepared by the aza-Diels-Alder reaction of simple dienes with the imine derived from ethyl glyoxylate and chiral 1-phenylethylamine; the cycloadditions are regiospecific, highly diastereoselective within the heterocyclic ring (>92percent exo with cyclic dienes, and 100percent endo with acyclic dienes), and lead to high asymmetric induction in most cases (average d.e. = 72percent).