205526-56-3

Basic information

• Product Name: (2R,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine
• Synonyms: (2R,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine
• CAS NO: 205526-56-3
• Molecular Weight: 357.495
• Mol File: 205526-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine(205526-56-3)
• EPA Substance Registry System: (2R,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine(205526-56-3)

Safety Data

• Hazardous Substances Data: 205526-56-3(Hazardous Substances Data)

Upstream product

• 205526-54-1 (2R,9R)-2,9-diphenyl-1-aza-4-oxabicyclo[4.3.0]nonane 
• 205526-53-0 (1R,1'R)-2-[N-(2,4,6-trimethoxybenzyl)-N-2'-hydroxy-1'-phenylethylamino]-5,5-ethylenedioxy-1-phenylpentane 
• 205526-52-9 (2R,4R)-2-(3-[1,3]Dioxolan-2-yl-propyl)-4-phenyl-3-(2,4,6-trimethoxy-benzyl)-oxazolidine 
• 204845-22-7 (R)-N-2,4,6-trimethoxybenzylphenylglycinol 
• 56613-80-0 D-2-phenylglycinol 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 205526-57-4 (+)-(R,R)-2,6-diphenylpiperidine 

Relevant articles and documents

Stereocontrolled preparation of cis- and trans-2,6-dialkylpiperidines via diastereoselective reaction of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives with Grignard reagents

We report here the syntheses of cis- and trans-2,6-disubstituted piperidines using chiral 1-aza-4-oxabicyclo[4.3.0]nonane synthon 1, which shows high reactivity toward nucleophilic attack at its C-5 position. Bicyclic compounds resembling synthon 1 were transformed to cis- and trans- 2,6-disubstituted piperidine derivatives via reactions with various Grignard reagents in a stereospecific manner. Using this methodology, (+)-solenopsin A (2b) and both enantiomers of isosolenopsin A (3a and 3b) were synthesized in an enantioselective manner from a single enantiomeric source.