205584-36-7

Upstream product

• 4799-68-2 3-benzyloxypropan-1-ol 
• 98-09-9 benzenesulfonyl chloride 
• 100-44-7 benzyl chloride 

Downstream Products

• 215929-81-0 (S)-(+)-4-(1-methylheptyloxycarbonyl)phenyl 4-(3-benzyloxyprop-1-oxy)biphenyl-4'-carboxylate 
• 439610-75-0 4-(3-benzyloxyprop-1-oxy)biphenyl-4'-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of new chiral smectic mesogenes with 4-(2-Phenylethyl)biphenyl and 4-[2-(3-Fluorophenyl)ethyl]biphenyl Molecular Cores

Two methods of synthesis of chosen 1-[4-(1-methyl-heptyloxycarbonyl)phenyl] -2-[4′-(2,2,3,3,4,4,4-heptafluorobutoxyalkoxy)biphenyl-4-yl]ethanes and 1-[3-fluoro-4-(1-methylheptyloxycarbonyl)phenyl]-2-[4′-(2,2,3,3,4,4, 4-heptafluorobutoxyalkoxy)bi-phenyl-4-yl]ethanes have been proposed, checked and compared. The compounds were prepared by Sonogashira coupling of 4-benzyloxy-4′-ethynylbiphenyl with appropriate 4-halobenzoate esters followed by parallel hydrogenation of ethynylene bridge and debenzylation of hydroxyl group. The 1-[4-(1-methylheptyloxycarbonyl)phenyl]-2-[4′- hydroxybiphenyl-4-yl]ethane and 1-[3-fluoro-4-(methoxycarbonyl)phenyl]-2- [4′-hydroxybiphenyl-4-yl]ethane thus obtained has been transformed into final products by Mitsunobu reaction with ω-(2,2,3,3,4,4,4- heptafluorobutoxy)alkan-1-ols, followed by the replacing of an ester terminal chain in the case of second method.

Synthesis and mesomorphic properties of chiral esters comprising partially fluorinated alkoxyalkoxy terminal chains and a 1-methylheptyl chiral moiety

Two structurally similar homologous series of chiral esters with partially fluorinated alkoxyalkoxy terminal chains are described. Their synthetic routes and mesomorphic properties, such as phase transitions temperatures and enthalpies, are characterized by polarizing optical microscope and differential scanning calorimetry.

Orthoconic antiferroelectrics. Synthesis and mesomorphic properties of optically active (S)-(+)-4-(1-methylheptyloxycarbonyl)phenyl 4′-(fluoroalkanoyloxyalkoxy)biphenyl-4-carboxylates and 4′-(alkanoyloxyalkoxy)biphenyl-4-carboxylates

Convenient methods for preparing optically active (S)-(+)-4-(1-methylheptyloxycarbonyl)-phenyl 4′-(ω-perfluoroalkanoyloxyalkoxy)- and 4′-(ω-alkanoyloxyalkoxy)biphenyl-4-carboxylates and their intermediates have been described and discussed. The phase transitions of the prepared esters have been investigated by differential scanning calorimetry.

Sordarin derivatives

PCT No. PCT/US97/18047 Sec. 371 Date Mar. 6, 1999 Sec. 102(e) Date Mar. 6, 1999 PCT Filed Oct. 3, 1997 PCT Pub. No. WO98/15178 PCT Pub. Date Apr. 16, 1998PURPOSE: To produce a novel antibiotic substance zofimarin having antimicrobial activity against fungi and obtain an antimicrobial agent containing the antibiotic substance zofimarin as an active constituent, by cultivating a microorganism, belonging to the genus Zopfiella and capable of producing the zofimarin. CONSTITUTION: An ascomycete belonging to the genus Zopfiella, e.g. Zopfiella marina; is cultivated. The cultivation is carried out according to general fungi, but artifical seawater is used in place of tap water in a liquid culture medium. A carbon source, nitrogen source, inorganic salt, etc., are added, and a defoaming agent is suitably used to carry out the cultivation at 20-30 DEG C. by the spinner culture method with aeration. After completing the cultivation, microbial cells are removed, and the resultant product in the supernatant liquid or filtrate is extracted and purified to afford the aimed zofimarin. The above-mentioned antibiotic substance is neutral colorless oily substance exhibiting the following properties; Soluble in methanol, ethanol and acetone and slightly soluble in water. Positive to the color reaction with iodine and sulfuric acid, etc., and expressed by the formula.

Sordarin derivatives

Sordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.