205584-67-4 Usage
Uses
Used in Pharmaceutical Industry:
6-chloro-5-fluoro-2,3-dihydro-1H-indole is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical and biological properties. Its potential as a precursor for the development of new drugs with specific therapeutic effects makes it a valuable compound in medicinal chemistry research.
Used in Agrochemical Industry:
6-chloro-5-fluoro-2,3-dihydro-1H-indole is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique properties may contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Chemical Research:
6-chloro-5-fluoro-2,3-dihydro-1H-indole is used as a valuable precursor for further chemical transformations and derivatization. Its presence of multiple halogen atoms allows for the creation of new molecules with specific properties, which can be applied in various fields of chemistry and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 205584-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,5,8 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 205584-67:
(8*2)+(7*0)+(6*5)+(5*5)+(4*8)+(3*4)+(2*6)+(1*7)=134
134 % 10 = 4
So 205584-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClFN/c9-6-4-8-5(1-2-11-8)3-7(6)10/h3-4,11H,1-2H2
205584-67-4Relevant academic research and scientific papers
Discovery of novel N -β- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
Yao, Chun-Hsu,Song, Jen-Shin,Chen, Chiung-Tong,Yeh, Teng-Kuang,Hung, Ming-Shiu,Chang, Chih-Chun,Liu, Yu-Wei,Yuan, Mao-Chia,Hsieh, Chieh-Jui,Huang, Chung-Yu,Wang, Min-Hsien,Chiu, Ching-Hui,Hsieh, Tsung-Chih,Wu, Szu-Huei,Hsiao, Wen-Chi,Chu, Kuang-Feng,Tsai, Chi-Hui,Chao, Yu-Sheng,Lee, Jinq-Chyi
experimental part, p. 166 - 178 (2011/02/28)
A novel series of N-linked β-d-xylosides were synthesized and evaluated for inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) in a cell-based assay. Of these, the 4-chloro-3-(4-cyclopropylbenzyl) -1-(β-d-xylopyranosyl)-1H-indole 19m was found to be the most potent inhibitor, with an EC50 value similar to that of the natural SGLT2 inhibitor phlorizin. Further studies in Sprague-Dawley (SD) rats indicated that 19m significantly increased urine glucose excretion in a dose-dependent manner with oral administration. The antihyperglycemic effect of 19m was also observed in streptozotocin (STZ) induced diabetic SD rats. These results described here are a good starting point for further investigations into N-glycoside SGLT2 inhibitors.
