122509-72-2Relevant articles and documents
Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.
Boes, Michael,Jenck, Francois,Martin, James R.,Moreau, Jean-Luc,Sleight, Andrew J.,et al.
, p. 2762 - 2769 (1997)
The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines are reported. The binding affinities of the compounds at 5HT2C and 5HT2A receptors (79% homology in the transmembrane domain)
Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives
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Page/Page column 18, (2010/11/25)
The present invention relates to Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R7 are as defined herein. The invention
Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole
Bentley, Jon M.,Davidson, James E.,Duncton, Matthew A. J.,Giles, Paul R.,Pratt, Robert M.
, p. 2295 - 2300 (2007/10/03)
An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ