205638-52-4

Upstream product

• 205638-41-1 3-Methoxymethoxy-2-oxo-cyclopentanecarboxylic acid ethyl ester 
• 205638-46-6 2-(1-Benzyl-3-methoxycarbonyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester 
• 205638-48-8 2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester 
• 205638-50-2 4-Benzyl-3-methoxymethoxy-5,8-dioxo-1,2,3,4,5,6,8,9-octahydro-7-oxa-4-aza-cyclopenta[a]naphthalene-9-carboxylic acid tert-butyl ester 
• 205638-43-3 2-[Benzyl-(2-methoxycarbonyl-acetyl)-amino]-3-methoxymethoxy-cyclopent-1-enecarboxylic acid ethyl ester 
• 205638-45-5 1-Benzyl-4-methoxy-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindine-3-carboxylic acid methyl ester 
• 205638-44-4 1-Benzyl-4-hydroxy-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindine-3-carboxylic acid methyl ester 
• 205638-42-2 2-Benzylamino-3-methoxymethoxy-cyclopent-1-enecarboxylic acid ethyl ester 
• 205638-40-0 2-Methoxymethoxy-hexanedioic acid diethyl ester 
• 99683-30-4 diethyl α-oxoadipate 
• 133634-32-9 2-hydroxy-adipic acid diethyl ester 
• 205638-51-3 4-Benzyl-9-ethyl-3-methoxymethoxy-5,8-dioxo-1,2,3,4,5,6,8,9-octahydro-7-oxa-4-aza-cyclopenta[a]naphthalene-9-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of c-ring modified analogues of camptothecin

Aiming at developing novel antitumor active compounds, we designed hexahydropyrano[3", 4"; 3", 4";]pyrido[5', 6', 4, 5]cyclopenta[1, 2-b]-quinoline which is a C-ring modified analogue of camptothecin. The compounds (9-14) were synthesized via Friedl?nder condensation and their in vitro cytotoxic activities were tested.