205641-02-7Relevant academic research and scientific papers
Rhodium-catalyzed ring opening of vinyl epoxides with alcohols and aromatic amines
Fagnou, Keith,Lautens, Mark
, p. 2319 - 2320 (2000)
(equation presented) [Rh(CO)2Cl]2 is an effective catalyst for the ring opening of vinyl epoxides with alcohols and aromatic amines under neutral conditions at room temperature. The reaction occurs with excellent diastereo- and regioselectivity (>20:1) giving the trans-1,2-amino alcohols or alkoxy alcohols for a wide range of substrates. The regio- and stereochemistry of these reactions is complementary to that typically obtained with palladium-catalyzed ring openings of vinyl epoxides.
Preparation of γ-heterosubstituted allylindium and diindium reagents and their reactions with carbonyl compounds
Hirashita, Tsunehisa,Kamei, Toshiya,Horie, Tomoaki,Yamamura, Hatsuo,Kawai, Masao,Araki, Shuki
, p. 172 - 177 (2007/10/03)
Various γ-heteroatom-substituted allylindium reagents were prepared, and their reactions with carbonyl compounds were examined. The reaction of 1,3-dibromopropene with metallic indium gave two types of organoindium species, γ-bromoallylindium and allylic
Effect of phosphorylation on the reaction rate of unnatural electrophiles with 2-keto-3-deoxy-6-phosphogluconate aldolase
Cotterill, Ian C.,Shelton, Michael C.,Machemer, Daniel E. W.,Henderson, Darla P.,Toone, Eric J.
, p. 1335 - 1341 (2007/10/03)
D-Glyceraldehyde is accepted as an electrophile by 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase (EC 4.1.2.14) at 1% the rate of natural substrate, D-glyceraldehyde 3-phosphate. Accordingly, it was expected that addition of a phosphate moiety at C3 or C4 of unnatural aldehydes would enhance their activity as electrophilic substrates. Furthermore, phosphate would act as a useful protecting group during synthetic manipulations of the aldol adduct. A variety of phosphorylated and non-phosphorylated aldehydes were synthesized and evaluated as substrates for KDPG aldolase. Although small variations in reaction rate were observed, phosphorylation failed to provide a universal rate enhancement. Evaluation of substrate kinetic parameters revealed that the high rate of reaction of D-glyceraldehyde 3-phosphate compared to related electrophiles is entirely due to the efficiency of turnover with little change in binding exhibited among various substrates.
Synthesis and Reactivity of Novel ?-Allylcyclopentadienyl Cobaltolactone Complexes
Christie, Steven D. R.,Cosset, Christophe,Hamilton, David R.,Kerr, William J.,O'Callaghan, John M.
, p. 2051 - 2052 (2007/10/02)
A range of novel cobaltolactone complexes are prepared under photolytic conditions from dicarbonylcyclopentadienylcobalt and vinyl epoxides; their subsequent reactivity under a selected series of reaction conditions is described.
