205644-26-4Relevant academic research and scientific papers
Polyester and N-methyl analogues of peptide nucleic acids: Synthesis and hybridization properties
Efimov,Buryakova,Choob,Chakhmakhcheva
, p. 2533 - 2549 (1999)
The synthesis of a set of homo-thymine analogues of peptide nucleic acids containing ester or N-methylamide linkages as well as analogues derived from trans-4-hydroxy-L-proline and their hybrids has been accomplished, and their binding affinity to complementary DNA and RNA strands was evaluated.
Peptide nucleic acids and their phosphonate analogues: II 1. Synthesis and physicochemical properties of hybrids containing serine and 4-hydroxyproline residues
Efimov,Buryakova,Choob,Chakhmakhcheva
, p. 545 - 555 (2007/10/03)
DNA mimics representing hybrids of peptide nucleic acids (PNA) or PNA phosphonate analogues (pPNA) with hydroxyamino acid derivatives, L-serine and L-4-trans-hydroxyproline, were synthesized. Preparative synthesis of monomers and some heterodimers derived from serine and hydroxyproline was developed. The corresponding mimic oligomers including pyrene-containing derivatives were prepared by the solid-phase automated synthesis. Ability of the resulting NA analogues to hybridize specifically to the DNA and RNA complementary strands was studied. It was shown that homothymine hybrids containing PNA or pPNA monomers alternating with hydroxyproline-derived monomers can form stable complexes with the complementary oligonucleotides, whose melting temperatures are close to those of equivalent PNA complexes.
