20566-80-7

Basic information

• Product Name: 3-CYANO-5-NITROBENZOTRIFLUORIDE
• Synonyms: 3-CYANO-5-NITROBENZOTRIFLUORIDE;3-NITRO-5-(TRIFLUOROMETHYL)BENZONITRILE;BUTTPARK 100\01-72;3-CYANO-5-NITROBENZOTRIFLUOROIDE;3-Cyano-5-nitrobenzotrifluoride[3-Nitro-5-(trifluoroMethyl)benzonitrile]
• CAS NO: 20566-80-7
• Molecular Formula: C₈H₃F₃N₂O₂
• Molecular Weight: 216.12
• Product Categories: Benzene series
• Mol File: 20566-80-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 241.817 °C at 760 mmHg
• Flash Point: 100.047 °C
• Appearance: /
• Density: 1.498 g/cm³
• Vapor Pressure: 0.035mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-CYANO-5-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CYANO-5-NITROBENZOTRIFLUORIDE(20566-80-7)
• EPA Substance Registry System: 3-CYANO-5-NITROBENZOTRIFLUORIDE(20566-80-7)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• Hazardous Substances Data: 20566-80-7(Hazardous Substances Data)

Usage

General Description

3-Cyano-5-nitrobenzotrifluoride is a complex chemical compound with the molecular formula of C7H2F3N3O2. It is recognized for containing the functional groups of nitrile, nitro, and trifluoromethyl, which contribute to its reactivity and functional potential in different chemical reactions. 3-CYANO-5-NITROBENZOTRIFLUORIDE mainly involves in the production of dyestuffs and pharmaceutical intermediates. Like other substances in the cyanobenzene family, it should be handled cautiously due to its potential toxicity. Information related to its physical properties, safety precautions, and potential hazards are typically provided in an MSDS (Material Safety Data Sheet), which should be consulted before handling or manipulating this chemical.

InChI:InChI=1/C8H3F3N2O2/c9-8(10,11)6-1-5(4-12)2-7(3-6)13(14)15/h1-3H

Upstream product

• 20566-89-6 3-nitro-5-(trifluoromethyl)benzamide 
• 782-79-6 3-nitro-5-trifluoromethyl-benzoyl chloride 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 

Downstream Products

• 1233324-80-5 5-(aminomethyl)-3-(trifluoromethyl)aniline 
• 49674-28-4 3-amino-5-(trifluoromethyl)benzonitrile 

Relevant articles and documents

PYRIDINE DERIVATIVES AS REARRANGED DURING TRANSFECTION (RET) KINASE INHIBITORS

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.