49674-28-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-amino-5-(trifluoromethyl)benzonitrile is utilized as a key intermediate in the synthesis of pharmaceutical and agrochemical compounds, leveraging its unique structural features to enhance the properties of the final products.
Used in Organic Synthesis:
In the realm of organic synthesis, 3-amino-5-(trifluoromethyl)benzonitrile is employed as a reagent, particularly for nucleophilic aromatic substitution reactions, where its trifluoromethyl group contributes to the formation of desired products with improved characteristics.
Used in Research and Development:
3-amino-5-(trifluoromethyl)benzonitrile is also used in research and development settings to explore new synthetic pathways and to understand the effects of trifluoromethylation on the reactivity and selectivity of various chemical reactions.

Upstream product

• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 20566-89-6 3-nitro-5-(trifluoromethyl)benzamide 
• 7440-44-0 pyrographite 
• 20566-80-7 3-nitro-5-(trifluoromethyl)benzonitrile 
• 57-14-7 N,N-Dimethylhydrazine 
• 557-21-1 zinc(II) cyanide 
• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 
• 73963-98-1 zinc cyanide 

Downstream Products

• 691877-03-9 3-bromo-5-(trifluoromethyl)benzonitrile 
• 691877-05-1 C₈H₃F₃IN 
• 880882-04-2 1-[3-amino-5-(trifluoromethyl)phenyl]ethanone 
• 1354947-79-7 2-{[3-cyano-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate 
• 1354946-95-4 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzonitrile 
• 1354947-80-0 {1-[3-cyano-5-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl acetate 
• 1354947-81-1 3-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-(trifluoromethyl)benzamide 
• 1354948-14-3 3-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-5-(trifluoromethyl)benzamide 
• 1354947-82-2 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzamide 
• 1229454-69-6 phenyl (3-cyano-5-(trifluoromethyl)phenyl)carbamate 
• 942072-08-4 ((R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 
• 942073-62-3 ((S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 

Relevant academic research and scientific papers

INHIBITORS OF NECROPTOSIS

The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the treatment of conditions associated with deregulated necroptosis.

TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

The present invention relates to novel tetrazole compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial. Formula (I) wherein A is: (II) or (III)

Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

Glucagon antagonists/inverse agonists

Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluotomethylbenzylamine represented by the following general formula (1), 1where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4. The process includes hydrogenating a trifluoromethylbenzonitrile by hydrogen in an organic solvent in the presence of ammonia and a catalyst containing a platinum group element. This trifluoromethylbenzonitrile is represented by the following general formula (2), 2where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine at an extremely high yield.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.