205692-60-0Relevant academic research and scientific papers
Light-responsive polymersomes with a charge-switch for targeted drug delivery
Bao, Chunyan,Chen, Rongrong,Fan, Jinyan,Lin, Qiuning,Wang, Chenxi,Yang, Huiting,Zhou, Yaowu,Zhu, Linyong
, p. 727 - 735 (2020)
Unlike the traditional block amphiphilic polymersomes, we herein report a lipid-like amphiphilic polymer that self-Assembles into photo-responsive polymersomes for drug delivery. The introduction of a quaternary ammonium moiety not only provides a hydrophilic segment of the polymersomes, but also enables electrostatic adsorption with folic acid, thus achieving the targeting of cancer cells with overexpression of folate receptor. Upon light irradiation, the photocleavage reaction of the o-nitrobenzyl moiety disintegrates polymersomes by changing the polymer structure from cationic amphiphilic state to zwitterionic hydrophilic state, thus realizing photo-Triggered drug release. The data showed that anticancer drugs (doxorubicin hydrochloride, DOX·HCl) can be loaded into the hydrophilic cavity of polymersomes and controllably released by photo-induced disintegration of polymersomes. Cellular assay showed that the active targeting of folic acid and photo-Triggered release endowed the DOX-loaded polymersomes with a higher cytotoxicity to HeLa cells. Such cationic polymersomes provide a novel strategy for designing effective and intelligent drug carriers, and have potential application as a novel integrated platform for targeted drug delivery.
Hydrogen bond-driven columnar self-assembly of electroluminescent D-A-D configured cyanopyridones
Vinayakumara,Ulla, Hidayath,Kumar, Sandeep,Pandith, Anup,Satyanarayan,Rao, D. S. Shankar,Prasad, S. Krishna,Adhikari, Airody Vasudeva
, p. 7385 - 7399 (2018/07/25)
Herein, we report the design and synthesis of a new series of flying bird-shaped liquid crystalline (LC) cyanopyridone derivatives with a D-A-D architecture, CPO-1 to CPO-4. Their mesomorphic, photophysical, electrochemical, and electroluminescence charac
Fluorescent columnar bis(boron difluoride) complexes derived from tetraketonates
Chen, Ya-Wen,Lin, Yen-Chun,Kuo, Hsiu-Ming,Lai, Chung K.
, p. 5465 - 5477 (2017/07/10)
Three new series of bis-(boron difluoride) complexes 1a-c derived from substituted tetraketonates 2a-c are reported, and their mesomorphic and optical properties have been investigated. Two single crystals of mesogenic ligand 2a (n = 6) and nonmesogenic d
Synthesis and optical/thermal behavior of new Azo photoisomerizable discotic liquid crystals
Westphal, Eduard,Bechtold, Ivan H.,Gallardo, Hugo
, p. 1319 - 1328 (2011/10/02)
In this study, discotic azo compounds were prepared by a reductive coupling of 5-nitroisophthalic acid followed by a convergent synthesis, resulting in five new examples of azo photoisomerizable discotic molecules, which differ from each other by the link
H-Bonded metallomesogens: preparation, characterization, and mesomorphic studies of (3-hydroxypropylimino)propan-1,2-diols
Chien, Chieh,Chen, Chun-Jung,Sheu, Hwo-Shuenn,Lee, Gene-Hsiang,Lai, Chung K.
scheme or table, p. 3583 - 3592 (2010/06/21)
Two series of new Schiff bases 2 (n=8, 12, 16) derived from (3-hydroxypropyl imino)propan-1, 2-diol with a hydroxyl group at C19/C20-position and their palladium complexes 1 were prepared and their mesomorphic properties investigated
Synthesis and characterization of a new class of liquid-crystalline, highly luminescent molecules containing a 2,4,6-triphenyl-1,3,5-triazine unit
Lee, Chi-Han,Yamamoto, Takakazu
, p. 3993 - 3996 (2007/10/03)
A new class of 2,4,6-triphenyl-1,3,5-triazine derivatives having long alkoxyl side chains have been synthesized by a Pd(0)/Cu(I)-catalyzed carbon-carbon coupling reaction. These compounds behave as liquid-crystalline materials and show quantum yields high
PREMIERS EXEMPLES DE SELS HETEROAROMATIQUES A QUATRE CHAINES PARAFFINIQUES POSSEDANT DES PROPRIETES MESOMORPHES COLONNAIRES
Strzelecka, H.,Jallabert, C.,Veber, M.,Davidson, P.,Levelut, A. M.,et al.
, p. 403 - 412 (2007/10/02)
Homologous series of diaryl-3,5 dithiolium-1,2 and diaryl-2,6 pyrylium salts, in which aryls possess two flexible alkoxy chains, were synthesized.With n>=8, dithiolium salts exhibit a columnar hexagonal mesophase.
NOUVEAUX SCRISTAUX LIQUIDES COLONNAIRES : CATIONS HETEROAROMATIQUES AVEC SIX CHAINES ALCOXY
Strzelecka, H.,Jallabert, C.,Veber, M.,Davidson, P.,Levelut, A. M.
, p. 395 - 402 (2007/10/02)
The synthesis of 2,4,6-triarylpyrylium tetrafluoroborates with six alkoxy chains is described.They exhibit Dho mesophases for a large range of temperatures (ca. 200 deg C).The compounds with n=5,8 and 12 are mesomorphic at room temperature.
