20570-20-1

Usage

Uses

Used in Organometallic Chemistry:
(Diethoxymethyl)diphenylphosphine oxide is used as a ligand for its ability to coordinate with transition metals, playing a crucial role in organometallic chemistry.
Used in Catalysis:
(Diethoxymethyl)diphenylphosphine oxide serves as a catalyst or a catalyst component in various chemical reactions, enhancing the efficiency and selectivity of the processes.
Used in Pharmaceutical Industry:
(Diethoxymethyl)diphenylphosphine oxide is utilized in the development of pharmaceuticals, potentially contributing to the synthesis of new drugs or improving existing ones.
Used in Material Science:
It is applied in material science for the synthesis of new materials or the modification of existing ones, possibly enhancing their properties for specific applications.
Used in Organic Synthesis:
(Diethoxymethyl)diphenylphosphine oxide is used as a reagent or catalyst in organic synthesis reactions, particularly for the formation of carbon-carbon and carbon-heteroatom bonds, contributing to the creation of complex organic molecules.

InChI:InChI=1/C17H21O3P/c1-3-19-17(20-4-2)21(18,15-11-7-5-8-12-15)16-13-9-6-10-14-16/h5-14,17H,3-4H2,1-2H3

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 1352709-73-9 (diphenylphosphoryl)(N,N-dimethylamino)chloromethane 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 86658-89-1 1-(Diphenyl-phosphinoyl)-1,1-diethoxy-4-phenyl-butan-2-ol 
• 86658-93-7 1-(Diphenyl-phosphinoyl)-1,1-diethoxy-2,6-dimethyl-hept-5-en-2-ol 
• 86670-60-2 1,1-Diethoxy-2-hydroxy-2-(4-methoxyphenyl)ethyl-1-(diphenylphosphine oxide) 
• 142632-71-1 r-2-Diphenylphosphinoyl-t-4,t-6-dimethyl-1,3-dioxane 
• 130506-61-5 r-2-Diphenylphosphinoyl-c-4,c-6-dimethyl-1,3-dioxane 
• 188546-72-7 1,1-Diethoxy-2-hydroxy-2-naphthylethyldiphenylphosphine oxide 
• 86659-12-3 2-((E)-4,4-Diethoxy-3-methyl-buta-1,3-dienyl)-1,3,3-trimethyl-cyclohexene 
• 86659-01-0 (4,4-Diethoxy-but-3-enyl)-benzene 
• 86659-05-4 (2,2-Diethoxy-1-methyl-vinyl)-benzene 
• 86659-00-9 (2,2-Diethoxy-vinyl)-cyclohexane 
• 86659-08-7 Diethoxymethylene-cyclohexane 
• 188546-86-3 [4-(2,2-Diethoxy-vinyl)-phenyl]-dimethyl-amine 
• 13049-42-8 phenylketene diethylacetal 
• 1071215-45-6 tert-Butyl-((R)-4,4-diethoxy-1-methyl-but-3-enyloxy)-diphenyl-silane 

Relevant academic research and scientific papers

Ambident reactivity of chloro(dialkylamino)-(diphenylphosphinoyl)methanes

The chemical properties of chloro(dialkylamino)(diphenylphosphinoyl) methanes have been studied using the simplest compound of this series, chloro(dimethylamino)(diphenylphosphinoyl)methane, as an example. Chloro- (dimethylamino)(diphenylphosphinoyl)methane shows ambident reactivity when reacting with electrophiles and nucleophiles depending on coreactant nature, it behaves as either electrophilic substrate or phosphorus nucleophile. This fact can be explained by its dissociation in solutions with both C-Cl bond cleavage to give (dimethylamino)- (diphenylphosphinoyl)methyl cation and Cl- anion and C-P bond cleavage to form chloro(dimethylamino)methyl cation and diphenylphosphinite anion. The capability of chloro(dimethylamino) (diphenylphosphinoyl)methane to produce spontaneously Ph2PO-anion allows us to recommend application in organic and organophosphorus synthesis as a synthetic equivalent (synthon) of diphenylphosphinite anion.

Asymmetric nucleophilic acylation of aldehydes via 1,1-heterodisubstituted alkenes

Aldehydes are asymmetrically acylated by a two step sequence that is initiated by a homologation step to 1,1-heterodisubstituted alkenes followed by asymmetric dihydroxylation. Thus, ketene O,S-acetals are efficiently prepared from aldehydes by a Peterson olefination with lithiated methoxy-phenylthiotrimethylsilyl methane 14 as the C-1 source. Although they are dihydroxylated with the Sharpless catalyst with moderate to good enantioselectivity (62-80% ee), the process is not efficient owing to the low chemical yields of the desired α-hydroxy methyl esters (7-37%). Use of the corresponding sulfoxide 24 or sulfon 25 led to an improved chemical yield of α-hydroxy methyl ester 19, but the stereoselectivity was diminished. In contrast, intermediate ketene O,O-acetals are prepared by a Horner-Wittig reaction with phosphine oxide 31 and are dihydroxylated both with good chemical and stereochemical yield. The concept is applicable to aromatic, aliphatic, and chiral aldehydes. For example, this short sequence allows exclusive and independent preparation of both diastereomeric heptoses 69 a and 69 b.

12-hetero substituted 6,11-ethano-6,11-dihydrobenzo (b) quinolizinium salts and compositions and method of use thereof

1-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.