205755-06-2Relevant academic research and scientific papers
Solid phase synthesis of oligonucleotides tethered to oligo-glucose phosphate tails
Adinolfi, Matteo,De Napoli, Lorenzo,Di Fabio, Giovanni,Iadonisi, Alfonso,Montesarchio, Daniela,Piccialli, Gennaro
, p. 6697 - 6704 (2002)
Oligonucleotides conjugated at both 3′ and 5′-ends with glucose residues, 4,6-linked through a phosphodiester bridge, have been synthesized by sequential addition of a 6-O-DMT-glucose-4-phosphoramidite building block following a standard automated ODN ass
Synthesis and biophysical characterization of G-rich oligonucleotides conjugated with sugar-phosphate tails
D'Onofrio,Erra,Di Fabio,Iadonisi,Petraccone,De Napoli,Barone,Balzarini,Giancola,Montesarchio
, p. 1225 - 1229 (2008/09/20)
A number of 5′-and 3′-glycoconjugates of the oligonucleotide 5′d(TGGGAG)3′ have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by thermal denaturation studies, via a detailed CD Q1 analysis. Copyright Taylor & Francis Group, LLC.
Use of controlled pore glass in solid phase oligosaccharide synthesis. Application to the semiautomated synthesis of a glyconucleotide conjugate
Adinolfi, Matteo,Barone, Gaspare,De Napoli, Lorenzo,Iadonisi, Alfonso,Piccialli, Gennaro
, p. 1953 - 1956 (2007/10/03)
Three polymetric supports (polystyrene. Tentagel and controlled pore glass) have been tested for solid phase synthesis of oligosaccharides based on the trichlorocctimidate methodology. Controlled pore glass has been found to yield satisfactory results wit
