665000-41-9Relevant academic research and scientific papers
A clean and one-pot synthesis of spiroindoline-pyranopyrazoles
Ahadi, Somayeh,Yasaei, Zahra,Bazgir, Ayoob
, p. 1090 - 1094 (2010)
(Chemical Equation Presented) Piperidine catalyzes efficiently the one-pot, four-component reaction of β-ketoesters, hydrazine hydrate, malononitrile, and isatines in aqueous media. The reaction was done at room temperature and the spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitriles were obtained with high yields and purity via an easy work-up procedure. These compounds were also investigated in vitro for antibacterial activities.
