205826-86-4

Basic information

• Product Name: (R)-α-[(2,2-DiMethyl-1-oxopropyl)aMino]-4-hydroxybenzeneacetic Acid
• Synonyms: (R)-α-[(2,2-DiMethyl-1-oxopropyl)aMino]-4-hydroxybenzeneacetic Acid;(2R)-2-[(2,2-dimethylpropanoyl)amino]-2-(4-hydroxyphenyl)acetic acid
• CAS NO: 205826-86-4
• Molecular Formula: C13H17NO4
• Molecular Weight: 251.28
• Product Categories: Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 205826-86-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 501.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.228±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.49±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: (R)-α-[(2,2-DiMethyl-1-oxopropyl)aMino]-4-hydroxybenzeneacetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α-[(2,2-DiMethyl-1-oxopropyl)aMino]-4-hydroxybenzeneacetic Acid(205826-86-4)
• EPA Substance Registry System: (R)-α-[(2,2-DiMethyl-1-oxopropyl)aMino]-4-hydroxybenzeneacetic Acid(205826-86-4)

Safety Data

• Hazardous Substances Data: 205826-86-4(Hazardous Substances Data)

Usage

Description

(R)-α-[(2,2-Dimethyl-1-oxopropyl)amino]-4-hydroxybenzeneacetic Acid, also known as Amoxicillin EP Impurity H, is a compound related to Amoxicillin (A634235). It is a pharmaceutical secondary standard used in the quality control of pharmaceutical products, providing a convenient and cost-effective alternative for laboratories and manufacturers.

Uses

Used in Pharmaceutical Quality Control:
(R)-α-[(2,2-Dimethyl-1-oxopropyl)amino]-4-hydroxybenzeneacetic Acid is used as a secondary standard for ensuring the quality and purity of pharmaceutical products, particularly those related to Amoxicillin. It helps in the development and validation of analytical methods, ensuring the accuracy and reliability of test results.
Used in Research and Development:
In the pharmaceutical industry, (R)-α-[(2,2-Dimethyl-1-oxopropyl)amino]-4-hydroxybenzeneacetic Acid is used as a research compound to study its properties, interactions, and potential applications in drug development. This may include investigating its effects on various biological systems and its potential as a therapeutic agent.
Used in Manufacturing:
(R)-α-[(2,2-Dimethyl-1-oxopropyl)amino]-4-hydroxybenzeneacetic Acid is utilized in the manufacturing process of pharmaceutical products, particularly those involving Amoxicillin. It serves as a reference material for the production of in-house working standards, aiding in the consistent and accurate production of medications.

Upstream product

• 22818-40-2 D-4-hydroxyphenylglycine 
• 3282-30-2 pivaloyl chloride 

Relevant articles and documents

Cp?Co(III)/MPAA-Catalyzed Enantioselective Amidation of Ferrocenes Directed by Thioamides under Mild Conditions

Cp?Cobalt(III)-catalyzed enantioselective C-H amidation of ferrocenes using monoprotected amino acids (MPAAs) as chiral ligands was developed. The reaction was performed under mild conditions in high yields (up to 97%) with moderate enantioselectivity (up to 77.5:22.5 er), providing a promising strategy to create planar chirality via base-metal-catalyzed enantioselective C-H activation.