20583-31-7

Basic information

• Product Name: 3-(4-NITROPHENYL)PYRAZOLE
• Synonyms: 3-(4-NITROPHENYL)PYRAZOLE;3-(4-NITRO-PHENYL)-1H-PYRAZOLE;BUTTPARK 15\04-54;1H-Pyrazole, 3-(4-nitrophenyl)-;3-(4-nitrophenyl)-2H-pyrazole;5-(4-Nitro-phenyl)-1H-pyrazole
• CAS NO: 20583-31-7
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17
• Mol File: 20583-31-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 195-197
• Boiling Point: 430 °C at 760 mmHg
• Flash Point: 213.9 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 3.36E-07mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.00±0.10(Predicted)
• CAS DataBase Reference: 3-(4-NITROPHENYL)PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-NITROPHENYL)PYRAZOLE(20583-31-7)
• EPA Substance Registry System: 3-(4-NITROPHENYL)PYRAZOLE(20583-31-7)

Safety Data

• Hazard Codes: Xi
• Statements: Xi:刺激性物质
• HazardClass: IRRITANT
• Hazardous Substances Data: 20583-31-7(Hazardous Substances Data)

Usage

General Description

3-(4-Nitrophenyl)Pyrazole is a synthetic chemical compound belonging to the class of phenylpyrazoles. It is characterized by a pyrazole ring which is connected to a phenyl ring bearing a nitro-group at the para-position. This chemical substance is typically used as a reagent in the synthesis of various other chemical compounds. It's commonly used in laboratories and can be instrumental in advancing scientific research. However, like with any other chemical, safety precautions should be taken while handling it as it may cause harm if not properly handled or disposed of. Potential hazards could include skin and eye irritation, and harmful if ingested or inhaled.

InChI:InChI=1/C9H7N3O2/c13-12(14)8-3-1-7(2-4-8)9-5-6-10-11-9/h1-6H,(H,10,11)

Upstream product

• 52376-81-5 p-Nitroacetophenone semicarbazone 
• 68-12-2 N,N-dimethyl-formamide 
• 68760-11-2 1-(4-nitrophenyl)-3-N,N-dimethylamino-2-propen-1-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 100-19-6 (4-nitrophenyl)ethanone 
• 63823-32-5 bis(methyloxy)methanamine 
• 49678-08-2 3-(4-nitrophenyl)-propenal 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 33282-25-6 5-(4-nitrophenyl)-isoxazole-3-carboxylic acid 
• 636-98-6 p-nitrobenzene iodide 
• 197093-16-6 N-tosyl-N-propargylhydrazine 
• 2458-26-6 3-phenylpyrazole 

Downstream Products

• 110462-53-8 1-acetyl-3-(4-nitro-phenyl)-1H-pyrazole 
• 89260-45-7 4-(1H-Pyrazol-3-yl)aniline 
• 89260-46-8 3-(3-Aminophenyl)-pyrazole 
• 73227-97-1 4-bromo-3-(4-nitrophenyl)-1H-pyrazole 
• 73387-59-4 1-methyl-3-(4-nitrophenyl)-1H-pyrazole 
• 1042917-64-5 3-(4-nitrophenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole 
• 916766-82-0 4-(1-methyl-1H-pyrazol-3-yl)aniline 
• 1415913-91-5 3-(n-hexyl)-4-(4-methoxyphenyl)-6-nitropyrazolo[5,1-a]isoquinoline 
• 1415913-89-1 4-(n-butyl)-3-(4-methoxyphenyl)-6-nitropyrazolo[5,1-a]isoquinoline 
• 1415913-88-0 4-methyl-6-nitro-3-phenylpyrazolo[5,1-a]isoquinoline 
• 1415913-73-3 diethyl 4,4'-(6-nitropyrazolo[5,1-a]isoquinoline-3,4-diyl)dibenzoate 
• 1415913-72-2 3,4-bis(4-chlorophenyl)-6-nitropyrazolo[5,1-a]isoquinoline 
• 1415913-71-1 3,4-bis(4-fluorophenyl)-6-nitropyrazolo[5,1-a]isoquinoline 

Relevant articles and documents

Design, synthesis, in silico, and in vitro evaluation of 3-phenylpyrazole acetamide derivatives as antimycobacterial agents

Mycobacterium tuberculosis (Mtb) is one of the most dangerous pathogens affecting immunocompetent and immunocompromised patients worldwide. Novel molecules, which are efficient and can reduce the duration of therapy against drug-resistant strains, are an

NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS FAK/AURORA KINASE INHIBITORS

This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.

Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions

Abstract An innovatively designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and phenyl hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chemistry. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol.