2059155-02-9Relevant articles and documents
INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
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Paragraph 0124-0127, (2021/04/16)
An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.
Synthetic method of difluoromethyl substituted oxane-2-one
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Paragraph 0042; 0046-0048, (2019/02/10)
The invention relates to a synthetic method of difluoromethyl substituted oxane-2-one. The synthetic method uses compound III as a raw material to prepare compound I via fluorination and deprotectiontwo-step reaction; the synthetic method is simple to per
BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
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Paragraph 0243-0244, (2017/01/23)
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.