205930-68-3Relevant academic research and scientific papers
Synthesis of [4-18F]-1-Bromo-4-fluorobenzene and its use in palladium-promoted cross-coupling reactions with organostannanes
Forngren, Tobias,Andersson, Yvonne,Lamm, Bo,Langstroem, Bengt
, p. 475 - 479 (2007/10/03)
A method of general interest for the introduction of a [4-18F]fluorophenyl structure into highly functional molecules has been developed. [4-18F]-1-Bromo-4-fluorobenzene 3 was obtained in a two-step reaction from [18F]fluo
Synthesis of 4-[18F]fluorophenyl-alkenes and -arenes via palladium-catalyzed coupling of 4-[18F]fluoroiodobenzene with vinyl and aryl tin reagents
Allain-Barbier, Lydie,Lasne, Marie-Claire,Perrio-Huard, Cecile,Moreau, Bernard,Barre, Louisa
, p. 480 - 489 (2007/10/03)
The cross-coupling reaction of 4-[18F]fluoroiodobenzene 3a with vinyl or aryl tin reagents in the presence of tetrakis(triphenylphosphine)palladium was found to provide a convenient and rapid method for the preparation of 4-[18F]fluorostyrene or 4-[18F]fluorobiphenyl within 45-50 min and 47% or 86% radiochemical yields, respectively, counted from 3a. (E)-N-{3-(4-[18F]fluorophenyl}prop-2-enyl]piperidine 2a was obtained within 45 min and in 80% radiochemical yield from 3a. 4-[18F]Fluorobromobenzene 4a was prepared in 24-48% yield from 2-nitro-5-bromobenzaldehyde and [18F]KF in 95 min. Acta Chemica Scandinavica 1998.
