205993-51-7

Basic information

• Product Name: (RS)-Boc-Pip-BZA
• Synonyms: (RS)-Boc-Pip-BZA
• CAS NO: 205993-51-7
• Molecular Weight: 318.416
• Mol File: 205993-51-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (RS)-Boc-Pip-BZA(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-Boc-Pip-BZA(205993-51-7)
• EPA Substance Registry System: (RS)-Boc-Pip-BZA(205993-51-7)

Safety Data

• Hazardous Substances Data: 205993-51-7(Hazardous Substances Data)

Usage

General Description

(RS)-Boc-Pip-BZA is a chemical compound that is composed of a Boc-protected piperazine (Boc-Pip) moiety attached to a benzotriazole (BZA) group. The Boc group refers to the tert-butoxycarbonyl protecting group, which is commonly used in organic synthesis to protect amines. Piperazine is a heterocyclic amine that is found in many pharmaceutical compounds, while benzotriazole is a common building block in the synthesis of organic compounds. The (RS) designation indicates that the compound is a racemic mixture of enantiomers. (RS)-Boc-Pip-BZA may have potential applications in organic synthesis, pharmaceuticals, and materials science.

Upstream product

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Relevant articles and documents

Amino acid derivatives with anticonvulsant activity

A series of benzylamides of N-alkylated, N-acylated or free nine cyclic and one linear amino acids as potential anticonvulsants have been synthesized. The structures of the obtained compounds were designed on the basis of the previously determined structure and physicochemical properties/anticvonvulsant activity relationship of the formerly synthesized compounds of this type. The obtained compounds were evaluated in mice after intraperitoneal (ip) administration, by maximal electroshock seizure test (MES test), subcutaneous (sc) pentylenetetrazol test (sc PTZ test) and by the rotarod neurotoxicity test (Tox test). The results were the basis for their classification into one of three classes of the Anticonvulsant Screening Project (ASP) of the Antiepileptic Drug Development Program (ADDP) of the NIH. Three selected compounds were tested quantitatively in rats after oral administration. The MES ED50, sc PTZ ED50, Tox TD50 were determined and their protective index (PI) values were calculated. Anticonvulsant activity of the most promising compound (15) was examined in different seizure models. The respective ED50 and PI values of this compound were as follows: against bicuculline, 73 and 1.4; against PTZ, 47 and 2.2; against strychnine, 73 and 1.4; against pilocarpine 156, and 0.7; against kainic acid (2-carboxy-4-isopropenyl-3-pyrrolidineacetic acid), 39 and 2.6; against AMPA (α-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid), 10 and 10.3 and against NMDA (N-methyl-D-Aspartic acid), 114 and 0.9.