20602-94-2Relevant academic research and scientific papers
pH-Amplified CRET Nanoparticles for In Vivo Imaging of Tumor Metastatic Lymph Nodes
Chen, Binlong,Li, Wenzhe,Liu, Jianxiong,Tang, Mingmei,Wang, Yaoqi,Wang, Yiguang,Wang, Zenghui,Xia, Heming,Yan, Yue,Yang, Ye,Yin, Qingqing,Zhang, Qiang,Zhao, Ruiyang
, p. 14512 - 14520 (2021)
Noninvasive imaging strategies have been extensively investigated for in vivo mapping of sentinel lymph nodes (SLNs). However, the current imaging strategies fail to accurately assess tumor metastatic status in SLNs with high sensitivity. Here we report p
Gold nano assembly with sensitization tumor radiotherapy and preparation method and application thereof
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Paragraph 0055-0057, (2021/10/20)
The invention provides a gold nano assembly with a tumor radiotherapy sensibilizing function and a preparation method and application thereof. The gold nano assembly has tumor location ph responsiveness and hypertonicity. The gold nano assembly is of a core-shell structure, gold nanoparticles are adopted as a core, and poly(2-(hexamethyleneimine)ethyl methacrylate block polyethylene glycol and poly(2-hexamethyleneimine)ethyl methacrylate block lipoic acid hydroxyl ethyl methacrylate are adopted as a shell. The gold nano assembly has a high absorption coefficient on gold X-rays, and the radiotherapy sensibilizing function. Polyethylene glycol has good biocompatibility, and the circulating time of the gold nano assembly in blood can be prolonged. 2-(hexamethyleneimine) has pH response performance, the size of the gold nano assembly becomes smaller, the gold nano assembly can permeate into the deep portion of a tumor more easily, and the killability of radiotherapy on tumor cells is further enhanced. The prepared gold nano assembly has excellent radiotherapy sensibilizing performance and stability, and application of the gold nano assembly in biomedicine is benefited.
BACTERIAL MEMBRANE NANOPARTICLES AS AN IMMUNOTHERAPY SYSTEM FOR CANCER TREATMENT
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Paragraph 0043-0044, (2020/04/09)
Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membran
Dual-Responsive Doxorubicin-Conjugated Polymeric Micelles with Aggregation-Induced Emission Active Bioimaging and Charge Conversion for Cancer Therapy
Su, Xin,Ma, Boxuan,Hu, Jun,Yu, Tao,Zhuang, Weihua,Yang, Li,Li, Gaocan,Wang, Yunbing
, p. 4050 - 4061 (2018/12/14)
In recent years, intelligent polymeric micelles with multifunctions are in urgent demand for cancer diagnosis and therapy. Herein, pH and redox dual-responsive prodrug micelles with aggregation-induced emission (AIE) active cellular imaging and charge conversion have been prepared for combined chemotherapy and bioimaging based on a novel doxorubicin-conjugated amphiphilic PMPC-PAEMA-P (TPE-co-HD)-ss-P (TPE-co-HD)-PAEMA-PMPC copolymer. The doxorubicin is conjugated via a pH cleavable imine linkage and can be packed in the hydrophobic core along with the glutathione (GSH)-sensitive disulfide bond. The DOX-conjugated inner core is sealed with a pH-responsive PAEMA as the "gate", which would rapidly open in the acidic condition, following the drug release and charge conversion-mediated acceleration of endocytosis. After an efficient internalization, the disulfide bond can be cleaved by the high concentration of GSH causing the further accelerated drug release. Meanwhile, intracellular drug delivery can be traced due to the AIE behavior of micelles. Moreover, great tumor inhibition in vitro and in vivo has been demonstrated for these DOX-conjugated micelles. This smart prodrug micelle system would be a desirable drug carrier for cancer therapy and bioimaging.
Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells
Zhou, Kejin,Wang, Yiguang,Huang, Xiaonan,Luby-Phelps, Katherine,Sumer, Baran D.,Gao, Jinming
supporting information; experimental part, p. 6109 - 6114 (2011/09/12)
Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by Foerster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications. Copyright
