206130-72-5

Upstream product

• 206130-69-0 3-(α-hydroxy-3,4-dimethoxybenzyl)-5,7-dimethoxyphthalide 
• 3465-69-8 5,7-dimethoxyphthalide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 6380-23-0 3,4-dimethoxystyrene 
• 91-52-1 2,4 dimethoxybenzoic acid 

Downstream Products

• 107584-58-7 3-(3,4-dimethoxybenzyl)-7-hydroxy-5-methoxyphthalide 
• 206130-75-8 (Z)-3-(3,4-dimethoxybenzylidene)-7-hydroxy-5-methoxyphthalide 

Relevant academic research and scientific papers

One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless pd-catalyzed oxidative coupling of benzoic acids and vinylarenes

A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.

Synthesis of naturally occurring (Z)-3-benzylidenephthalide and (+/-) 3-benzylphthalides

A convenient method, involving generation of phthalide anion, is described for the synthesis of naturally occurring (Z) 3-benzylidenephthalide (5) and (+/-) 3-benzyl phthalides (6c, 10a-c), starting from phthalides (7a-b).