206255-41-6

Upstream product

• 206255-61-0 C₂₁H₂₆O₃ 
• 1323952-38-0 C₁₄H₂₀O₃ 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 53346-05-7 (R)-2-benzyloxypropanal 
• 89104-01-8 (2R,3R)-2-(benzyloxy)-5-hexen-3-ol 
• 1449419-17-3 C₁₅H₂₀O₃S₂ 
• 1449419-19-5 C₁₆H₂₄O₃S₂ 
• 1449419-21-9 C₂₃H₃₀O₃S₂ 
• 1401864-53-6 C₁₅H₂₀O₃S₂ 

Downstream Products

• 588728-50-1 (6R,7R)-7-Benzyloxy-4-hydroxy-6-(4-methoxy-benzyloxy)-octan-2-one 
• 588728-53-4 (4S,6R,7R)-7-Benzyloxy-6-(4-methoxy-benzyloxy)-oct-1-en-4-ol 
• 588728-60-3 {1-[3-benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-but-3-enyloxy}-tert-butyl-dimethyl-silane 
• 588728-54-5 (3R,5R,6R)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-heptanal 
• 639786-32-6 (E)-4-[(3aS,4S,6R,7aS)-6-((2R,3R)-3-Benzyloxy-2-hydroxy-butyl)-4-hydroxy-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-4-methyl-pent-2-enal 
• 639786-31-5 (E)-4-[(3aS,4S,6R,7aS)-6-((2R,3R)-3-Benzyloxy-2-hydroxy-butyl)-4-methoxy-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-4-methyl-pent-2-enal 
• 639786-36-0 (3aS,4S,6R,7aS)-6-((2R,3R)-3-Benzyloxy-2-hydroxy-butyl)-4-((E)-4-hydroxy-1,1-dimethyl-but-2-enyl)-4-methoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one 
• 627091-01-4 (R)-2-[(2R,3R)-3-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-6-[(E)-4-(4-methoxy-benzyloxy)-1,1-dimethyl-but-2-enyl]-2,3-dihydro-pyran-4-one 
• 588728-56-7 (2S,6S)-6-[(2R,3R)-3-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-2-methoxy-2-[(E)-4-(4-methoxy-benzyloxy)-1,1-dimethyl-but-2-enyl]-dihydro-pyran-3-one 
• 588728-55-6 (2S,3S,4S,6S)-6-[(2R,3R)-3-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-2-methoxy-2-[(E)-4-(4-methoxy-benzyloxy)-1,1-dimethyl-but-2-enyl]-tetrahydro-pyran-3,4-diol 
• 639786-30-4 (3aS,4S,6R,7aS)-6-[(2R,3R)-3-Benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-4-methoxy-4-[(E)-4-(4-methoxy-benzyloxy)-1,1-dimethyl-but-2-enyl]-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one 
• 588728-61-4 (E)-(9R,11R,12R)-12-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-1,11-bis-(4-methoxy-benzyloxy)-4,4-dimethyl-tridec-2-ene-5,7-dione 
• 588728-62-5 Benzoic acid (2S,4S,6R)-6-[(2R,3R)-3-benzyloxy-2-(4-methoxy-benzyloxy)-butyl]-2-methoxy-2-[(E)-4-(4-methoxy-benzyloxy)-1,1-dimethyl-but-2-enyl]-3-oxo-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity

Aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity, bound to and activated protein kinase Cδ (PKCδ), that is involved in tumor suppression and apoptosis. To examine the contribution of PKCδ to the anti-proliferative activity of aplog-1, we synthesized 27-methyl and 27-methoxy derivatives that differed in the ability to activate PKCδ. Activators of PKCδ like aplog-1 and 27-(R)-Me-aplog-1 strongly inhibited the growth of several cancer cell lines. On the other hand, 27-(S)-Me-aplog-1 and 27-O-Me-aplog-1 without the ability to activate PKCδ, exhibited only weak growth inhibitory activity against these cell lines. These results suggest indirectly that the activation of PKCδ might be involved in the anti-proliferative activity of aplog-1 against aplog-sensitive cancer cell lines.

Synthetic approaches to the bottom half fragment for bryostatin 11

An approach towards the stereoselective synthesis of the bottom half fragment of bryostatin 11 is described. Key steps -include asymmetric aldol and Saksena-Evans reduction reactions -to construct multiple stereogenic centers and thioketalization-lactoniz

BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES

Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or improved recognition domains are disclosed, including methods of preparing and utilizing the same.

BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES

Biologically active compounds related to the bryostatin family of compounds, including methods of utilizing the same.