206256-69-1Relevant academic research and scientific papers
Synthesis of 1,5-benzothiazepines: Part XIX - Syntheses of 10-substituted benzopyranobenzothiazepines as prospective cardiovascular agents
Upreti, Mani,Pant, Seema,Dandia, Anshu,Pant, Umesh C.,Goel, Anil K.,Patnaik, Gyanendra K.
, p. 1185 - 1188 (2007/10/03)
10-Substituted-2-chloro-6a,7-dihydro-6H-7-(4-substituted phenyl)-6-phenyl-[1]benzopyrano[3,4-c][1,5]benzothiazepines (3a-l) have been synthesized by reacting (E)-6-chloro-3-(4-chloro/methoxybenzylidene)flavanones (2a,b) with 5-substituted-2-aminobenzenethiols (1a-f) by reflux heating in dry toluene containing piperidine (1:1). The products have been tested for purity by TLC and microestimation of nitrogen. IR and 1H NMR and mass spectral studies have enabled the assignment of structures. Bioassay screening of 3e,f,h and i shows mild analgesic and anticonvulsant activity.
