Ethyl 8-bromo-4-chloroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 8-bromo-4-chloroquinoline-3-carboxylate
CAS No.:206258-97-1
Molecular Formula:C12H9BrClNO2
Molecular Weight:314.566
Hs Code.:2933499090
DSSTox Substance ID:DTXSID40392315
Wikidata:Q72453609
Mol file:206258-97-1.mol

Synonyms:Ethyl 8-bromo-4-chloroquinoline-3-carboxylate;206258-97-1;MFCD00173385;3-Quinolinecarboxylic acid, 8-bromo-4-chloro-, ethyl ester;8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester;Ethyl8-bromo-4-chloroquinoline-3-carboxylate;Oprea1_849231;SCHEMBL6293263;8-Bromo-4-chloro-quinoline-3-carboxylic acid ethyl ester;DTXSID40392315;MLHAFVCMBUQWKC-UHFFFAOYSA-N;SC1871;TQ0118;AKOS000196330;SB21146;SY034287;CS-0097495;FT-0685759;6J-024;A879529;W-206542;8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester, AldrichCPR

Suppliers and Price of Ethyl 8-bromo-4-chloroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl8-bromo-4-chloroquinoline-3-carboxylate
100mg
$ 45.00

SynQuest Laboratories
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
1 g
$ 87.00

SynQuest Laboratories
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
5 g
$ 336.00

Sigma-Aldrich
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester Aldrich
1g
$ 277.00

Matrix Scientific
Ethyl 8-bromo-4-chloroquinoline-3-carboxylate 95%
5g
$ 4070.00

Matrix Scientific
Ethyl 8-bromo-4-chloroquinoline-3-carboxylate 95%
1g
$ 1097.00

J&W Pharmlab
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 97%
5g
$ 6880.00

J&W Pharmlab
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 97%
500mg
$ 998.00

J&W Pharmlab
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 97%
1g
$ 1880.00

Crysdot
Ethyl8-bromo-4-chloroquinoline-3-carboxylate 98%
5g
$ 268.00

Total 24 raw suppliers

Chemical Property of Ethyl 8-bromo-4-chloroquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:6.33E-06mmHg at 25°C
Boiling Point:378.3ºC at 760 mmHg
Flash Point:182.6ºC
PSA：39.19000
Density:1.578g/cm3
LogP:3.82740
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:312.95052
Heavy Atom Count:17
Complexity:290

Purity/Quality:

97% ^*data from raw suppliers

Ethyl8-bromo-4-chloroquinoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2C(=C1Cl)C=CC=C2Br

Technology Process of Ethyl 8-bromo-4-chloroquinoline-3-carboxylate

There total 6 articles about Ethyl 8-bromo-4-chloroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35975-57-6
ethyl-8-bromo-4-hydroxyquinolyl-3-carboxylic acid ethyl ester

: 206258-97-1
ethyl 4-chloro-8-bromo-3-quinolinecarboxylate

Guidance literature:: With trichlorophosphate;
DOI:10.1016/S0960-894X(03)00127-6

Reference yield:

: 692764-07-1,35975-57-6
ethyl 8-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 206258-97-1
ethyl 4-chloro-8-bromo-3-quinolinecarboxylate

Guidance literature:: With thionyl chloride; N,N-diisorpopylformamide; In toluene; at 100 ℃; for 3h;

Reference yield:

: 615-36-1
2-bromoaniline

: 206258-97-1
ethyl 4-chloro-8-bromo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 120 - 150 °C

1.2: Heating

2.1: POCl₃

With trichlorophosphate;
DOI:10.1016/S0960-894X(03)00127-6