206268-28-2

Upstream product

• 4816-81-3 p-tosyl-L-alanine 
• 206268-20-4 1-N-tert-butyloxycarbonyl-4-N-methyl-(1,4)-diaminobutan-2-ol 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 206268-15-7 2-methyl-5-tert-butyloxycarbonylaminomethyl-(1,2)-isoxazolidine 
• 21957-58-4 N-(p-toluenesulfonyl)-DL-alanine 

Relevant academic research and scientific papers

Synthesis of perhydrodiazepinones as new putative peptidomimetics

New functionalized 7-membered azaheterocycles (perhydrodiazepinones) have been designed as new scaffolds supposed to mimick peptide γ-turns constrained by an ethylene bridge. They were synthesized by either lactam cyclisation on an aminoacid compound outcoming from a glutamic acid derivative starting material or through an intramolecular Mitsunobu reaction on diaminoalcohol linear precursors. Furthermore, as a new strategy useful for combinatorial chemistry, the second synthesis has been investigated on a soluble polymer support (PEG).

Synthesis of new perhydro-(1,4)-diazepin-2-ones as constrained peptidomimetics

New access to substituted perhydro-(1,4)-diazepin-2-ones has been developed through either a Mitsunobu reaction or an amide bond formation for the cyclisation key step.