206278-20-8

Basic information

• Product Name: 2-fluoro-3-(diphenylhydroxymethyl)pyrazine
• CAS NO: 206278-20-8
• Molecular Weight: 280.301
• Mol File: 206278-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-fluoro-3-(diphenylhydroxymethyl)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-(diphenylhydroxymethyl)pyrazine(206278-20-8)
• EPA Substance Registry System: 2-fluoro-3-(diphenylhydroxymethyl)pyrazine(206278-20-8)

Safety Data

• Hazardous Substances Data: 206278-20-8(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 4949-13-7 2-fluoropyrazine 

Downstream Products

• 206278-46-8 5-Chloro-2-(diphenyl-trimethylsilanyloxy-methyl)-3-fluoro-pyrazine 
• 206278-39-9 (5-Chloro-3-fluoro-pyrazin-2-yl)-diphenyl-methanol 
• 206278-38-8 (3-Fluoro-5-iodo-pyrazin-2-yl)-diphenyl-methanol 

Relevant articles and documents

Functionalization by metallation of fluoropyrazine. Diazines XXI

Lithiation of fluoropyrazine followed by quenching with various electrophiles was successfully achieved and was used to synthesize new pyrazine derivatives. A further lithiation of 2-fluoro-3-substitute, pyrazines allowed access to 2,3,6-trisubstituted pyridazine derivatives. As an application, a one-pot synthesis of a quinuclidinylfluoropyrazine has been performed. When the 3-substituent bears a TMS protected alcohol, functionalization via metallation at C6 position provides tetrasubstituted pyrazines in good yield.