4949-13-7

Basic information

• Product Name: 2-FLUOROPYRAZINE 98
• Synonyms: 2-FLUOROPYRAZINE 98;2-Fluoropyrazine 98%;Fluoropyrazine;2-Fluoro-1,4-diazine;Pyrazine, 2-fluoro-;Fluoropyrazine 97%
• CAS NO: 4949-13-7
• Molecular Formula: C₄H₃FN₂
• Molecular Weight: 98.0797
• Product Categories: Piperazines
• Mol File: 4949-13-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 84/0.25mm
• Flash Point: 21℃
• Appearance: /
• Density: 1.213
• Refractive Index: 1.469
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.27±0.10(Predicted)
• CAS DataBase Reference: 2-FLUOROPYRAZINE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPYRAZINE 98(4949-13-7)
• EPA Substance Registry System: 2-FLUOROPYRAZINE 98(4949-13-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 10-22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 1993BF 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 4949-13-7(Hazardous Substances Data)

Usage

General Description

2-Fluoropyrazine 98 is a chemical compound with a high purity level of 98%. It is a fluorinated derivative of pyrazine, and is commonly used in the pharmaceutical and chemical industries. 2-Fluoropyrazine 98 is known for its strong aromatic odor and is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is a versatile compound that can be used as a reagent in organic synthesis and as an intermediate in the production of fine chemicals. 2-Fluoropyrazine 98 is also known for its stability and compatibility with other chemicals, making it a valuable component in industrial applications.

Upstream product

• 14508-49-7 2-chloropyrazin 

Downstream Products

• 206278-19-5 2-fluoro-3-(1-phenylhydroxymethyl)pyrazine 
• 21352-21-6 2-(N-acetylamino)pyrazine 
• 5049-61-6 2-Aminopyrazine 
• 1624605-89-5 N-((4S,6S)-4-(2-fluoro-5-(pyrazin-2-yloxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide 
• 5049-62-7 sodium pyrazine-2-sulfonate 
• 29460-97-7 2-phenylpyrazine 
• 206278-26-4 2-fluoro-3-iodopyrazine 

Relevant articles and documents

Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations is the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alcohol adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alcohol substituent (R), tetramethylammonium fluoride tert-amyl alcohol (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80 °C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles is demonstrated.

Acyl azolium fluorides for room temperature nucleophilic aromatic fluorination of chloro- and nitroarenes

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.

Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies

(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAFanh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAFanh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.