206346-40-9

Upstream product

• 108-05-4 vinyl acetate 
• 262844-05-3 methyl (2R,3S)-2-O-t-butyldimethylsilyl-2,3-dihydroxy-3-(p-chlorophenyl)propionate 
• 186581-53-3 diazomethane 
• 220820-72-4 (2S,4R,5S)-4-O-t-butyldimethylsilyl-1,2-O-isopropylidene-1,2,4,5-tetrahydroxy-5-(p-chlorophenyl)pentan-3-one 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 

Downstream Products

• 426815-09-0 methyl (2S,3R)-2-acetoxy-3-bromo-3-(4'-chlorophenyl)propanoate 

Relevant academic research and scientific papers

The asymmetric synthesis of β-aryl-α-hydroxy esters from β-aryl-α,β-dihydroxy esters

α,β-Dihydroxy-β-aryl esters obtained via Sharpless asymmetric dihydroxylation (AD) of substituted cinnamate esters are reduced by sequential reaction with trimethyl orthoacetate and acetyl bromide followed by catalytic hydrogenolysis in methanol to give enantiomerically enriched β-aryl-α-hydroxy esters.

Aldol reactions with erythrulose derivatives: Stereoselective synthesis of differentially protected syn-α,β-dihydroxy esters

Boron enolates of 1-O-silylated erythrulose 3,4-acetonides prepared with Brown's chloro-dicyclohexylborane/tertiary amine system have been shown to react with achiral aldehydes in a highly stereoselective way to yield a 1,2- syn/1,3-syn stereoisomer. Thro

Lipase-catalyzed transesterification as a practical route to homochiral syn-1,2-diols. The synthesis of the taxol side chain

syn-2,3-Dihydoxy-3-phenyl-propanoic acid methyl ester (1a) and its simple derivatives (1b-e) are efficiently resolved in LPS-catalyzed transesterification, leading to the synthesis of the taxol side chain and analogs from both resolved enantiomers.