206346-40-9

Basic information

• Product Name: methyl (2R,3S)-2,3-dihydroxy-3-(4'-chlorophenyl)propanoate
• Synonyms: methyl (2R,3S)-2,3-dihydroxy-3-(4'-chlorophenyl)propanoate
• CAS NO: 206346-40-9
• Molecular Weight: 230.648
• Mol File: 206346-40-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl (2R,3S)-2,3-dihydroxy-3-(4'-chlorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2R,3S)-2,3-dihydroxy-3-(4'-chlorophenyl)propanoate(206346-40-9)
• EPA Substance Registry System: methyl (2R,3S)-2,3-dihydroxy-3-(4'-chlorophenyl)propanoate(206346-40-9)

Safety Data

• Hazardous Substances Data: 206346-40-9(Hazardous Substances Data)

Upstream product

• 262844-05-3 methyl (2R,3S)-2-O-t-butyldimethylsilyl-2,3-dihydroxy-3-(p-chlorophenyl)propionate 
• 186581-53-3 diazomethane 
• 220820-72-4 (2S,4R,5S)-4-O-t-butyldimethylsilyl-1,2-O-isopropylidene-1,2,4,5-tetrahydroxy-5-(p-chlorophenyl)pentan-3-one 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 108-05-4 vinyl acetate 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 

Downstream Products

• 426815-09-0 methyl (2S,3R)-2-acetoxy-3-bromo-3-(4'-chlorophenyl)propanoate 

Relevant articles and documents

The asymmetric synthesis of β-aryl-α-hydroxy esters from β-aryl-α,β-dihydroxy esters

α,β-Dihydroxy-β-aryl esters obtained via Sharpless asymmetric dihydroxylation (AD) of substituted cinnamate esters are reduced by sequential reaction with trimethyl orthoacetate and acetyl bromide followed by catalytic hydrogenolysis in methanol to give enantiomerically enriched β-aryl-α-hydroxy esters.

Lipase-catalyzed transesterification as a practical route to homochiral syn-1,2-diols. The synthesis of the taxol side chain

syn-2,3-Dihydoxy-3-phenyl-propanoic acid methyl ester (1a) and its simple derivatives (1b-e) are efficiently resolved in LPS-catalyzed transesterification, leading to the synthesis of the taxol side chain and analogs from both resolved enantiomers.