206346-76-1Relevant academic research and scientific papers
Synthesis of 1,1-difluoroalkenes via α,α-difluoro-β-lactones
Ocampo, Rogelio,Dolbier, William R.,Paredes, Rodrigo
, p. 41 - 50 (1998)
A new method for the general synthesis of 1,1-difluoroalkenes from ketones is presented.The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α,α-difluoro-β-hydroxy acids, followed by cycliza
