Journal of Fluorine Chemistry p. 41 - 50 (1998)
Update date:2022-08-05
Topics:
Ocampo, Rogelio
Dolbier, William R.
Paredes, Rodrigo
A new method for the general synthesis of 1,1-difluoroalkenes from ketones is presented.The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α,α-difluoro-β-hydroxy acids, followed by cycliza
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Doi:10.1021/ja01612a070
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