20635-13-6

Upstream product

• 1122-82-3 isothiocyanatocyclohexane 
• 766-93-8 N-cyclohexylformamide 
• 931-53-3 Cyclohexyl isocyanide 
• 1158245-85-2 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanethioic S-acid 
• 119072-55-8 tert-butylisonitrile 
• 1158966-28-9 C₂₃H₂₃NO₅S 
• 62-53-3 aniline 
• 74-90-8 hydrogen cyanide 
• 108-91-8 cyclohexylamine 

Downstream Products

• 21198-18-5 4-cyclohexyl-thiosemicarbazide 
• 756819-68-8 4-cyclohexyl-3-methyl-4H-1,2,4-triazole 
• 14041-93-1 N-Isopropyl-N'-cyclohexyl-N-acetyl-formamidin 
• 1122-82-3 isothiocyanatocyclohexane 

Relevant academic research and scientific papers

Facile microwave-assisted synthesis of thioformamides from isocyanides and carbon disulfide

A new, fast, solvent-free and efficient method is provided to prepare thioformamides by reacting isocyanides derivatives, carbon disulfide and benzylamine under microwave irradiation.

Fe3O4@GlcA@Cu-MOF: A Magnetic Metal-Organic Framework as a Recoverable Catalyst for the Hydration of Nitriles and Reduction of Isothiocyanates, Isocyanates, and Isocyanides

A novel magnetic metal-organic framework (Fe3O4@GlcA@Cu-MOF) has been prepared and characterized by spectroscopic, microscopic, and magnetic techniques. This magnetically separable catalyst exhibited high catalytic activity for nitrile hydration and the ability to reduce isothiocyanates, isocyanates, and isocyanides with excellent activity and selectivity without any additional reducing agent.

Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent

Thioformamides are easily prepared-under full chemocontrol-through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent. The high electrophilicity of the starting materials enables the straightforward addition of the hydride ion, thus constituting a reliable and high-yielding method for obtaining variously functionalized thioformamides. Sensitive chemical groups to the reduction conditions such as nitro, ester, alkene, azo, azide and keto groups do not interfere with the chemoselectivity of the process. Moreover, the stereochemical information embodied in the starting material is fully retained in the final products. The synthetic potential of the selected thioformamide template is also briefly discussed.

Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles

The preparation of N-thioformyl peptides from amino thioacids and isonitriles at room temperature is described.

Thio FCMA intermediates as strong acyl donors: A general solution to the formation of complex amide bonds

(Chemical Equation Presented) Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitril

Microwave-assisted synthesis of substituted 1,2,4-triazoles

An efficient synthesis of substituted 1,2,4-triazoles has been extended, utilising a wide range of N-substituted amides and hydrazides.

Novel reduction of isothiocyanates to thioformamides with SmI2 and tert-butyl alcohol in the presence of HMPA

Isocyanates react with SmI2 and tert-butyl alcohol in the presence of HMPA to give thioformamides in excellent yields under mild conditions.