206352-49-0

Upstream product

• 103046-35-1 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 31804-69-0 (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) 
• 100-44-7 benzyl chloride 
• 36455-21-7 3-benzyloxy-4-methoxyphenylethylamine 
• 63909-29-5 (E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 

Relevant academic research and scientific papers

Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine

(R)-(+)-nor-Roefractine (1) was synthesized by the Bischler-Napieralski route, using asymmetric reduction of the 1,2-didehydro precursor imine with sodium (S)-N-CBZ-prolinyloxyborohydride. Compound 1 was able to displace [3H]-raclopride (a D2 dopamine receptor-selective ligand) from its specific binding sites in rat striatum with selectivity vs [3H]-SCH23390 (D1 dopamine receptor-selective ligand).