(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

Base Information

Chemical Name:(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline
CAS No.:206352-49-0
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

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Chemical Property of (S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

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Technology Process of (S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

There total 6 articles about (S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 103046-35-1
6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

: 206352-49-0
(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium tris[(S)-N-benzyloxycarbonylproline]hydroborate; In dichloromethane; at -30 ℃; for 7h;
DOI:10.1021/np980008a

Reference yield:

: 36455-21-7
3-benzyloxy-4-methoxyphenylethylamine

: 206352-49-0
(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / POCl₃ / CH₂Cl₂ / 3 h / Heating

3: 49 percent / sodium (S)-N-CBZ-prolinyloxyborohydride / CH₂Cl₂ / 7 h / -30 °C

With sodium hydroxide; trichlorophosphate; sodium tris[(S)-N-benzyloxycarbonylproline]hydroborate; In dichloromethane;
DOI:10.1021/np980008a

Reference yield:

: 63909-29-5
(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

: 206352-49-0
(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

2: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

3: 89 percent / POCl₃ / CH₂Cl₂ / 3 h / Heating

4: 49 percent / sodium (S)-N-CBZ-prolinyloxyborohydride / CH₂Cl₂ / 7 h / -30 °C

With sodium hydroxide; lithium aluminium tetrahydride; trichlorophosphate; sodium tris[(S)-N-benzyloxycarbonylproline]hydroborate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/np980008a