206353-51-7

Upstream product

• 40359-46-4 4-(2-formylphenoxy)-butyric acid ethyl ester 
• 90-02-8 salicylaldehyde 
• 1187020-22-9 2,3-dihydro-benzo[b]oxepine-4-carboxylic acid methyl ester 
• 6786-30-7 3,4-dihydro-1-benzoxepin-5(2H)-one 
• 1027332-53-1 5-oxo-2,3,4,5-tetrahydro-benzo[b]loxepine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

5-OXO-2, 3,4,5-TETRAHYDRO-BENZO[B]OXEPINE-4-CARBOXYLIC ACID AMIDES AND 2,3-DIHYDRO-BENZO[B]OXEPINE-4-CARBOXYLIC ACID AMIDES FOR TREATMENT AND PREVENTION OF DIABETES TYP 1 AND 2

The present invention relates to novel compounds of general formula (I) for use as glucokinase activators in the treatment of diabetes and obesity.

Efficient preparation of medium ring oxygen heterocycles

We achieved efficient preparation of medium ring oxygen heterocycles (1), 1-benzoxepines and 1-benzoxocines, by applying intramolecular Claisen-type condensation in dialkyl carbonate with metal alcoholate. Furthermore, we accomplished the preparation of 2