206357-76-8

Basic information

• Product Name: 2-(4-ISOPROPYLBENZOYL)PYRIDINE
• Synonyms: 2-(4-ISOPROPYLBENZOYL)PYRIDINE
• CAS NO: 206357-76-8
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• Mol File: 206357-76-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354°C at 760 mmHg
• Flash Point: 175.7°C
• Appearance: /
• Density: 1.068g/cm³
• Vapor Pressure: 3.46E-05mmHg at 25°C
• Refractive Index: 1.561
• PKA: 3.02±0.10(Predicted)
• CAS DataBase Reference: 2-(4-ISOPROPYLBENZOYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ISOPROPYLBENZOYL)PYRIDINE(206357-76-8)
• EPA Substance Registry System: 2-(4-ISOPROPYLBENZOYL)PYRIDINE(206357-76-8)

Safety Data

• Hazardous Substances Data: 206357-76-8(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic aromatic compound

Structure

Pyridine ring with a benzoyl group at the 2-position and an isopropyl group at the 4-position

Common uses

Building block in organic synthesis

Pharmaceutical properties

Potential anti-inflammatory and analgesic activities

Synthesis applications

Used in the synthesis of various pharmaceuticals and other organic compounds

InChI:InChI=1/C15H15NO/c1-11(2)12-6-8-13(9-7-12)15(17)14-5-3-4-10-16-14/h3-11H,1-2H3

Upstream product

• 586-61-8 4-iso-propylbromobenzene 
• 857146-20-4 (4-isopropylphenyl)-2-pyridylmethanol 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 928046-56-4 2-[1-(4-isopropylphenyl)-3-methyl-1-butenyl]pyridine 
• 928046-34-8 1-(4-isopropylphenyl)-3-methyl-1-(2-pyridyl)-1-butanol 

Relevant articles and documents

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter

Methylphenidate analogues, in which the carbomethoxy has been replaced by an alkyl group and with different phenyl substituents, have been synthesized and tested in monoamine transporter assays. As predicted from a pharmacophore model, most of the RR/SS diastereomers showed high potency as dopamine reuptake inhibitors. Analogues with a 4-chlorophenyl group and an unbranched initial alkyl atom had consistently enhanced selectivity for the dopamine transporter. The most potent compounds were those with a three- or four-carbon chain. The "inactive" RS/SR diastereomers showed substantial activity when the phenyl substituent was 3,4-dichloro. On a locomotor assay, one compound was found to have a slow onset and a long duration of action. The activity of these compounds provides additional evidence for a conformational/superposition model of methylphenidate with cocaine-like structures. A ketone analogue, obtained by hydrogenating a previously described vinylogous amide, had activity similar to that of methylphenidate.