206358-45-4

Upstream product

• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 7148-74-5 2-Bromopropionyl chloride 

Downstream Products

• 175844-92-5 (4S,5R)-1-((S)-2-Benzylamino-propionyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 176018-06-7 (4S,5R)-1-((R)-2-Benzylamino-propionyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 206358-50-1 (4R,5S)-1,5-Dimethyl-4-phenyl-3-((R)-2-piperidin-1-yl-propionyl)-imidazolidin-2-one 
• 143359-36-8 (4R,5S)-1,5-Dimethyl-4-phenyl-3-((R)-2-phenylsulfanyl-propionyl)-imidazolidin-2-one 
• 176018-05-6 (4R,5S,2'S)-3-(α-bromopropionyl)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 169219-76-5 (4S,5R)-1-N-(phenylacetyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 175844-90-3 (4R,5S,2'R)-3-(α-bromopropionyl)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 206358-49-8 (4R,5S)-1,5-Dimethyl-4-phenyl-3-((R)-2-pyrrolidin-1-yl-propionyl)-imidazolidin-2-one 

Relevant academic research and scientific papers

A new dynamic resolution strategy for asymmetric synthesis

Two different and complementary auxiliary based dynamic resolution processes have been developed; the use of crystallisation induced dynamic resolution and/or dynamic kinetic resolution enables the preparation of either enantiomeric product using a single chiral auxiliary as illustrated in the preparation of D or L-alinine derivatives.

A practical method for the acylation of 2-imidazolidinone and 2-oxazolidinone chiral auxiliaries with 2-bromoacyl halides

Optimised conditions for the acylation of (S)-4-(1-methyl-ethyl)-oxazolidin-2-one 4, (R)-4-phenyloxazolidin-2-one 5 and 4-(R), (5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 3 with 2-bromoacyl halides were developed. For imidazolidin-2-one 3 the optimum con