206361-53-7Relevant academic research and scientific papers
A modular approach to a new class of phosphinohydrazones and their use in asymmetric allylic alkylation reactions
Widhalm, Michael,Abraham, Michael,Arion, Vladimir B.,Saarsalu, Siret,Maeorg, Uno
, p. 1971 - 1982 (2010)
A group of five phosphino hydrazones with a pendant binaphthyl unit as a chiral modifier has been synthesized from non-racemic 2,2′- bis(bromomethyl)-1,1′-binaphthyl and 3,3′-diiodo-2,2′- bis(bromomethyl)-1,1′-binaphthyl as the key intermediates. Their efficiency as chiral ligands in palladium-catalyzed allylic alkylation reactions has been investigated showing up to 95% ee under optimized conditions. X-ray diffraction structures of mono- and dimeric Pd complexes are also reported.
