20638-61-3Relevant academic research and scientific papers
Tertiary Amine Promoted Asymmetric Aldol Reaction of Aldehydes
Gut, Bartosz,Mlynarski, Jacek
supporting information, p. 5075 - 5078 (2015/08/18)
The direct asymmetric self-aldol reactions of various α-oxyaldehydes catalyzed by tertiary amines have been demonstrated. By using 10 mol-% of quinine catalyst, dimerization products have been prepared in high yields, with good anti-diastereocontrol, and up to 80% ee. The presented enolate-mediated synthesis of protected tetrose sugars has never been accomplished before by chiral tertiary amine organocatalysts.
