20642-94-8Relevant academic research and scientific papers
Synthesis of aryl urea derivatives from aryl amines and aryl isocyanates
Usharani,Bhujanga Rao,Reddy,Dubey
, p. 1802 - 1806 (2011/12/22)
The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl] amino]phenoxy]-N-methylpyridine-2- carboxamide] having potential antiproliferative activity.
Selective N,N-dimethylation of primary aromatic amines with methyl alkyl carbonates in the presence of phosphonium salts
Selva, Maurizio,Perosa, Alvise,Tundo, Pietro,Brunelli, Davide
, p. 5770 - 5773 (2007/10/03)
In the presence of onium salts, at 140-170 °C. methyl alkyl carbonates [1a-c, ROCO2Me, R = MeO(CH2)2[O(CH 2)2]n; n = 2-0, respectively] react with primary aromatic amines (XC6H4NH2, X = p-OMe, p-Me, H, p-Cl, p-CO2Me, o-Et, and 2,3-Me2C 6H3NH2) to yield the corresponding N,N-dimethyl derivatives (ArNMe2) with high selectivity (up to 96%) and good isolated yields (78-95%). Phosphonium salts (e.g., Ph3PEtI and n-Bu4PBr) are particularly efficient catalysts. Overall, a solvent-free reaction is coupled with safe methylating agents (1a-c) made from nontoxic dimethyl carbonate.
Indirect electrochemical carbonylation of aromatic amines with a palladium catalyst
Hartstock, Frederick W.,Herrington, Deborah G.,McMahon, Launa B.
, p. 8761 - 8764 (2007/10/02)
Aromatic amines are converted to carbamates under very mild conditions, using carbon monoxide, palladium (II) acetate and copper (II) acetate in combination with anodic reoxidation.
