206434-66-4Relevant articles and documents
Nucleophilic aromatic substitution on 3-aroyl-2-arylbenzothiophenes. Rapid access to raloxifene and other selective estrogen receptor modulators
Schmid, Christopher R.,Sluka, James P.,Duke, Kristin M.
, p. 675 - 678 (2007/10/03)
Versatile, mild and high yielding methods for nucleophilic aromatic substitution of 2-dialkylamino-1-ethoxides and related nucleophiles on 3- aroyl-2-arylbenzothiophene nuclei are presented. A short synthesis of raloxifene is detailed.
SUBSTITUTED BENZO(B)THIOPHENE COMPOUNDS HAVING ACTIVITY AS SELECTIVE ESTROGEN RECEPTOR MODULATORS
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, (2008/06/13)
The present invention provides compounds with nitrogen, sulfur or carbon linked basic side chains of formula STR1 where R 1 and R. sup.2 are independently hydrogen, halo, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyl, alkoxycarbonyloxy, arylcarbonylox