206441-91-0Relevant academic research and scientific papers
Polymer-assisted solution phase (PASP) chemical library synthesis
Flynn, Daniel L.,Devraj, Rajesh V.,Naing, Win,Parlow, John J.,Weidner, John J.,Yang, Syaulan
, p. 219 - 243 (2007/10/03)
Resin-capture methods are described which mediate the rapid purification of solution-phase chemical library reactions. This strategy, termed polymer- assisted solution phase (PASP) synthesis, utilizes complementary- functionalized resins to remove reactants, byproducts, reagents, or products from solution-phase as a purification technique. Enhancements to PASP technology include the use of in situ chemical tagging techniques and bifunctional, chemically-tagged reagents when artificially-imparted sequestration functionality is desirable.
Solution-phase parallel synthesis of a benzoxazinone library using complementary molecular reactivity and molecular recognition (CMR/R) purification technology
Parlow, John J.,Flynn, Daniel L.
, p. 4013 - 4031 (2007/10/03)
A solution-phase synthesis of a benzoxazinone library is described. The five-step synthesis is accomplished using combinations of complementary molecular reactivity and molecular recognition (CMR/R) purification concepts, including reactant-sequestering r
