206446-52-8Relevant academic research and scientific papers
Preparation of phospho-L-azatyrosine suitably protected for the synthesis of signal transduction related peptides. A correction
Yao, Zhu-Jun,Ye, Bin,Miyoshi, Kengo,Otaka, Akira,Burke Jr., Terrence R.
, p. 428 - 430 (1998)
Synthesis of Nα-Fmoc 4-O,O-(di-tert-butyl)phospho-L-azatyrosine (6) and its use in Fmoc-based solid-phase peptide synthesis are reported. The di-tert-butyl phospho protecting groups were removed during TFA-mediated cleavage of the finished peptide (10) from the resin, providing the free phosphoazatyrosine-containing peptide directly. This is in contrast to diethyl phospho protection we previously reported [Ye, B.; Otaka, A.; Burke, T. R., Jr. Synlett. 1996, 459-460] in which the diethyl protection has proven impractical to remove. Due to incorrect assignment of starting material, the title compound of this latter report should be corrected to the isomeric L-β-(3-hydroxy-2-pyridyl)-alanine compound (5).
