20647-85-2Relevant academic research and scientific papers
Synthesis of tetrazolopiperazine building blocks by a novel multi-component reaction
Umkehrer, Michael,Kolb, Jürgen,Burdack, Christoph,Ross, Günther,Hiller, Wolfgang
, p. 6421 - 6424 (2004)
A novel Ugi-five-centre-four-component reaction (U-5C-4CR) of aldehydes, primary amines, trimethylsilylazide and 2-isocyanoethyltosylate yielding tetrazolopiperazine building blocks is described.
One-Pot Synthesis of Cyclic Isothioureas
Wang, Jun,Sun, Zhihua
supporting information, p. 1751 - 1756 (2021/08/27)
The one-pot synthesis of cyclic isothioureas is reported. This method provides a straightforward and efficient approach to the synthesis of a broad range of cyclic isothioureas with yields of up to 90% and in quantities of up to 5 g. It is of great value for the preparation of classic organocatalysts, such as benzotetramisole and homobenzotetramisole.
TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS
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Page/Page column 50; 51, (2015/07/07)
The present invention relates to tetrahydro-tetrazolo[l,5-a]pyrazine compounds of formula (I), wherein R1 denotes -R3, -CH2-R3 or -CO-R3; R2 denotes Ar2, Hetar2 or C3-7-cycloalkyl; and R3 denotes Ar3, Hetar3 or C3-7-cycloalkyl. These compounds are useful for inhibiting the retinoid-related orphan receptor γ (ROR γ, ROR-gamma) and for the prevention and/or treatment of medical conditions affected by ROR γ activity such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colitis, asthma, autoimmune hepatitis or type 1 and type 2 diabetes.
