206534-51-2Relevant academic research and scientific papers
Total synthesis of (+)-homopumiliotoxin 223G
Aoyagi, Sakae,Hasegawa, Yoko,Hirashima, Shintaro,Kibayashi, Chihiro
, p. 2149 - 2152 (1998)
A new practical route for the first total synthesis of (+)- homopumiliotoxin 223G is described, in which the palladium-catalyzed carbonylation of the vinyl iodide, leading to efficient construction of the quinolizidine nucleus incorporating the (Z)-alkylidene side chain, is the key strategic clement. Another key feature of this synthesis involves the Lewis acid-induced chelation-controlled propargylation using the allenylsilane with complete diastereoselectivity.
